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Literature summary extracted from

  • Iino, S.; Horiguchi, K.; Nojyo, Y.
    Interstitial cells of Cajal are innervated by nitrergic nerves and express nitric oxide-sensitive guanylate cyclase in the guinea-pig gastrointestinal tract (2008), Neuroscience, 152, 437-448.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 NO nitric oxide-sensitive guanylate cyclase Cavia porcellus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Cavia porcellus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Cavia porcellus NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Cavia porcellus
-
 adult female Hartley guinea pigs
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 blood vessel smooth muscle Cavia porcellus
-
4.6.1.2 colon smooth muscle, low enzyme expression Cavia porcellus
-
4.6.1.2 gastrointestinal tract smooth muscle and myenteric layer Cavia porcellus
-
4.6.1.2 large intestine
-
 Cavia porcellus
-
4.6.1.2 additional information analysis of sGC in gastrointestinal tissue, immunohistochemic analysis Cavia porcellus
-
4.6.1.2 neuron
-
 Cavia porcellus
-
4.6.1.2 smooth muscle gastrointestinal tract, muscularis mucosae and vasculature Cavia porcellus
-
4.6.1.2 stomach smooth muscle, low enzyme expression Cavia porcellus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Cavia porcellus 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP NO is a major signaling molecule in the gastrointestinal tract, and released NO inhibits muscular contraction. The actions of NO are mediated by stimulation of NO-sensitive sGC and a subsequent increase in cGMP concentration Cavia porcellus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 nitric oxide-sensitive guanylate cyclase
-
 Cavia porcellus
4.6.1.2 NO-sensitive GC
-
 Cavia porcellus
4.6.1.2 sGC
-
 Cavia porcellus
4.6.1.2 soluble guanylate cyclase
-
 Cavia porcellus