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Literature summary extracted from

  • Jung, M.E.; Agarwal, R.; Simpkins, J.W.
    Ethanol withdrawal posttranslationally decreases the activity of cytochrome c oxidase in an estrogen reversible manner (2007), Neurosci. Lett., 416, 160-164.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.1.1.9 additional information counteracting relationship exists between the effects of withdrawal and 17beta-estradiol on the activity of COX in a subunit specific manner, which may not alter protein synthesis Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 additional information ethanol withdrawal decreases the activity of total COX, COX I, and COX IV. Estrogen treatment (17beta-estradiol) prevents the effects of withdrawal on the activities of total COX and COX IV but not COX I. Neither withdrawal nor 17beta-estradiol alter the protein levels of the subunits Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 young adult female Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 brain
-
 Rattus norvegicus
-
7.1.1.9 cerebellum
-
 Rattus norvegicus
-
7.1.1.9 additional information cortex Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 COX
-
 Rattus norvegicus
7.1.1.9 COX I
-
 Rattus norvegicus
7.1.1.9 COX IV
-
 Rattus norvegicus
7.1.1.9 cytochrome c oxidase
-
 Rattus norvegicus