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Literature summary extracted from

  • Sanchez, G.; Colettis, N.; Vazquez, P.; Cervenansky, C.; Aguirre, A.; Quillfeldt, J.A.; Jerusalinsky, D.; Kornisiuk, E.
    Muscarinic inhibition of hippocampal and striatal adenylyl cyclase is mainly due to the M(4) receptor (2009), Neurochem. Res., 34, 1363-1371.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.1 dopamine 140% activation at 0.1 mM, activation in hippocampus and striatum, the stimulation is partially inhibited, up to 48%, by oxotremorine, inhibition of stimulation is blocked by muscarinic toxin MT3, purified from Dendroaspis angusticeps snake venom, overview Rattus norvegicus
4.6.1.1 forskolin activation in hippocampus, striatum, and amygdala. The stimulation is inhibited in vivo by oxotremorine, which is not affected by scopolamine. M4 is the main subtype responsible for muscarinic inhibition of forskolin-stimulated enzyme, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.1 ATP Rattus norvegicus
-
 3',5'-cyclic-AMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.1 Rattus norvegicus
-
 male Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.1 amygdala low activity Rattus norvegicus
-
4.6.1.1 corpus striatum
-
 Rattus norvegicus
-
4.6.1.1 hippocampus
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.1 ATP
-
 Rattus norvegicus 3',5'-cyclic-AMP + diphosphate
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.6.1.1 35
-
 assay at Rattus norvegicus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.6.1.1 7.5
-
 assay at Rattus norvegicus