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Literature summary extracted from

  • Oudit, G.Y.; Imai, Y.; Kuba, K.; Scholey, J.W.; Penninger, J.M.
    The role of ACE2 in pulmonary diseases - relevance for the nephrologist. (2009), Nephrol. Dial. Transplant., 24, 1362-1365.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.4.17.23 medicine enhancing ACE2 action may serve to provide additional therapeutic benefits patients with cardiovascular and diabetic kidney disease. Increased ACE2 activity by the use of human recombinant ACE2 and/or a small molecule activator(xanthenone) of ACE2 may represent potential new therapies for lung, cardiovascular and kidney diseases by providing dual beneficial effects by antagonizing angiotensin II action while generating angiotensin-(1-7) Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.17.23 additional information Homo sapiens ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects ?
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Organism

EC Number Organism UniProt Comment Textmining
3.4.17.23 Homo sapiens Q9BYF1
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.17.23 heart the endothelium-bound carboxypeptidase is expressed in the heart and kidney Homo sapiens
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3.4.17.23 kidney the endothelium-bound carboxypeptidases is expressed in the heart and kidney. ACE2 is expressed in renal tubular epithelium, vascular smooth muscle cells of the intrarenal arteries and in the glomeruli Homo sapiens
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.17.23 angiotensin I + H2O
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Homo sapiens angiotensin-(1-9) + Leu
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?
3.4.17.23 angiotensin II + H2O
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Homo sapiens angiotensin-(1-7) + Phe
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?
3.4.17.23 additional information ACE2 plays a key role in pulmonary, cardiovascular and hypertensive and diabetic kidney diseases. ACE2 plays a pivotal role in maintaining a balanced status of the RAS synergistically with ACE by exerting counter-regulatory effects Homo sapiens ?
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?
3.4.17.23 additional information ACE2 functions predominantly as a carboxymonopeptidase with a substrate preference for hydrolysis between proline and a hydrophobic or basic C-terminal residue Homo sapiens ?
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?

Synonyms

EC Number Synonyms Comment Organism
3.4.17.23 ACE2
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Homo sapiens
3.4.17.23 angiotensin converting enzyme 2
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Homo sapiens