EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | CO | - |
Mus musculus | |
4.6.1.2 | CORM-2 | i.e. CO-releasing molecule-2, a tricarbonyldichlororuthenium(II) dimer | Mus musculus | |
4.6.1.2 | YC-1 | i.e. 1-benzyl-3-(5'-hydroxymethyl-2'-furyl-)-indazol, a sGC sensitizer, able to potentiate CO- and CORM-2-induced relaxations in wild-type mice | Mus musculus |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
4.6.1.2 | additional information | construction and phenotype of sGCalpha1 KO mice, expression levels of sGC subunits are altered in the mutant compared to the wild-type mice, the KO mice show reduced enzyme activation and induced muscle relaxation by CO, overview | Mus musculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
4.6.1.2 | 1H-[1,2,4]oxadiazolo-[4,3-a]quinoxalin-1-one | i.e. ODQ, a sGC inhibitor | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
4.6.1.2 | soluble | - |
Mus musculus | - |
- |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | Mus musculus | - |
3',5'-cyclic GMP + diphosphate | - |
? | |
4.6.1.2 | additional information | Mus musculus | soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview | ? | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
4.6.1.2 | Mus musculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
4.6.1.2 | intestine | - |
Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
4.6.1.2 | GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
4.6.1.2 | additional information | soluble guanylyl cyclase alpha1/alpha2 subunits are involved in the relaxant effect of CO and CORM-2, i.e. CO-releasing molecule-2, on enteric smooth muscle, overview | Mus musculus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
4.6.1.2 | sGC | - |
Mus musculus |
4.6.1.2 | soluble guanylyl cyclase | - |
Mus musculus |