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Literature summary extracted from

  • Strauss, D.M.; Wuttke, D.S.
    Characterization of protein-protein interactions critical for poliovirus replication: analysis of 3AB and VPg binding to the RNA-dependent RNA polymerase (2007), J. Virol., 81, 6369-6378.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.48 expressed in Escherichia coli BL21(DE3) cells Enterovirus C

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.7.48 vesicle 3AB is a membrane-binding protein responsible for the localization of the polymerase to the membranous vesicles at which replication occurs Enterovirus C 31982
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Organism

EC Number Organism UniProt Comment Textmining
2.7.7.48 Enterovirus C
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 strains 3D and 3AB
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Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.48 nucleoside triphosphate + RNAn VPg (a peptide comprising the 3B region of protein 3AB) is the 22-residue soluble product of 3AB cleavage and serves as the protein primer for RNA replication Enterovirus C diphosphate + RNAn+1
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 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.48 RNA-dependent RNA polymerase
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 Enterovirus C