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Literature summary extracted from

  • Leipnitz, G.; Seminotti, B.; Haubrich, J.; Dalcin, M.B.; Dalcin, K.B.; Solano, A.; de Bortoli, G.; Rosa, R.B.; Amaral, A.U.; Dutra-Filho, C.S.; Latini, A.; Wajner, M.
    Evidence that 3-hydroxy-3-methylglutaric acid promotes lipid and protein oxidative damage and reduces the nonenzymatic antioxidant defenses in rat cerebral cortex (2008), J. Neurosci. Res., 86, 683-693.
    View publication on PubMed

Application

EC Number Application Comment Organism
4.1.3.4 medicine 3-hydroxy-3-methylglutaryl CoA lyase deficiency is a rare autosomal recessive mitochondrial disease characterized by a deficiency in the enzyme 3-hydroxy-3-methylglutaryl CoA lyase Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.1.3.4 mitochondrion
-
 Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA Rattus norvegicus
-
 Acetyl-CoA + acetoacetate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.3.4 Rattus norvegicus P97519 Wistar rat
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.1.3.4 cerebral cortex
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.3.4 (S)-3-Hydroxy-3-methylglutaryl-CoA
-
 Rattus norvegicus Acetyl-CoA + acetoacetate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.3.4 3-Hydroxy-3-methylglutaryl-CoA lyase
-
 Rattus norvegicus
4.1.3.4 HMGCL
-
 Rattus norvegicus