Any feedback?
Literature summary extracted from
- Microsomal prostaglandin E2 synthase-1 (mPGES-1): a novel anti-inflammatory therapeutic target (2008), J. Med. Chem., 51, 4059-4067.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | interleukin-1beta | - |
Homo sapiens | |
| 5.3.99.3 | LPS | - |
Homo sapiens |
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | medicine | mPGES-1 plays a role in atherosclerosis, stroke, inflammation, pain and fever | Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | 15-deoxy-DELTA12,14-prostaglandin J2 | - |
Homo sapiens |  |
| 5.3.99.3 | 2-(2-chloro-6-fluorophenyl)-9-fluoro-3,6-dihydro-7H-benzo[h]imidazo[4,5-f]isoquinolin-7-one | - |
Homo sapiens | |
| 5.3.99.3 | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
| 5.3.99.3 | 2-[6-(2-cyclopropylethoxy)-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
| 5.3.99.3 | 2-[6-bromo-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
| 5.3.99.3 | 2-[6-chloro-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
| 5.3.99.3 | 2-[6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | - |
Homo sapiens | |
| 5.3.99.3 | 3-(1-benzothiophen-2-yl)-2-bromo-5-hydroxycyclopent-2-en-1-one | - |
Homo sapiens | |
| 5.3.99.3 | 3-benzamidocarbazole | - |
Homo sapiens | |
| 5.3.99.3 | 3-[1-(4-chlorobenzyl)-5-(2-fluoro-5-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
| 5.3.99.3 | 3-[1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
| 5.3.99.3 | 3-[3-(benzylsulfanyl)-1-(4-chlorobenzyl)-5-[4-[(4-chloro-2-fluorophenyl)ethynyl]phenyl]-1H-indol-2-yl]-2,2-dimethylpropanoic acid | - |
Homo sapiens | |
| 5.3.99.3 | 4-(4-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole | - |
Homo sapiens | |
| 5.3.99.3 | 5-(4-cyclohexylphenyl)-1-[4-(1-methylethoxy)benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
| 5.3.99.3 | 5-(4-tert-butylphenyl)-1-[4-(1-methylethoxy)benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
| 5.3.99.3 | 5-(4-tert-butylphenyl)-3-[4-(1-methylethoxy)phenyl]-1-[4-[(1-methylethyl)amino]benzyl]-1H-indole-2-carboxylic acid | - |
Homo sapiens | |
| 5.3.99.3 | 7-hydroxy-N,N'-bis(2,4,6-trimethylphenyl)naphthalene-1,3-disulfonamide | - |
Homo sapiens | |
| 5.3.99.3 | acetaminophen | - |
Homo sapiens | |
| 5.3.99.3 | arachidonic acid | - |
Homo sapiens | |
| 5.3.99.3 | biarylimidazole | - |
Homo sapiens | |
| 5.3.99.3 | cysteinyl leukotriene LTC4 | - |
Homo sapiens | |
| 5.3.99.3 | eicosapentaenoic acid | - |
Homo sapiens | |
| 5.3.99.3 | methyl 4-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]but-3-ynoate | - |
Homo sapiens | |
| 5.3.99.3 | MK-886 | - |
Homo sapiens | |
| 5.3.99.3 | N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-(trifluoromethyl)benzamide | - |
Homo sapiens | |
| 5.3.99.3 | NS-398 | - |
Homo sapiens | |
| 5.3.99.3 | resveratrol | - |
Homo sapiens | |
| 5.3.99.3 | sulindac sulfide | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | Homo sapiens | - |
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 5.3.99.3 | brain | - |
Homo sapiens | - |
| 5.3.99.3 | heart | - |
Homo sapiens | - |
| 5.3.99.3 | kidney | - |
Homo sapiens | - |
| 5.3.99.3 | lung | - |
Homo sapiens | - |
| 5.3.99.3 | seminal vesicle | - |
Homo sapiens | - |
| 5.3.99.3 | spleen | - |
Homo sapiens | - |
| 5.3.99.3 | stomach | - |
Homo sapiens | - |
| 5.3.99.3 | testis | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 5.3.99.3 | (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate | - |
Homo sapiens | (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 5.3.99.3 | microsomal prostaglandin E2 synthase-1 | - |
Homo sapiens |
| 5.3.99.3 | mPGES-1 | - |
Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 5.3.99.3 | glutathione | - |
Homo sapiens | |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 5.3.99.3 | 0.0000007 | - |
- |
Homo sapiens | 2-[6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
| 5.3.99.3 | 0.0000008 | - |
- |
Homo sapiens | biarylimidazole | |
| 5.3.99.3 | 0.0000009 | - |
- |
Homo sapiens | 2-[6-(2-cyclopropylethoxy)-9-(3-hydroxy-3-methylbutyl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
| 5.3.99.3 | 0.0000009 | - |
- |
Homo sapiens | 2-[6-bromo-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
| 5.3.99.3 | 0.0000009 | - |
- |
Homo sapiens | 2-[6-chloro-9-(3-hydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]benzene-1,3-dicarbonitrile | |
| 5.3.99.3 | 0.000001 | - |
- |
Homo sapiens | 2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile | |
| 5.3.99.3 | 0.0000017 | - |
- |
Homo sapiens | methyl 4-[6-bromo-2-(2-chloro-6-fluorophenyl)-1H-phenanthro[9,10-d]imidazol-9-yl]but-3-ynoate | |
| 5.3.99.3 | 0.00006 | - |
- |
Homo sapiens | 3-[3-(benzylsulfanyl)-1-(4-chlorobenzyl)-5-[4-[(4-chloro-2-fluorophenyl)ethynyl]phenyl]-1H-indol-2-yl]-2,2-dimethylpropanoic acid | |
| 5.3.99.3 | 0.0003 | - |
- |
Homo sapiens | arachidonic acid | |
| 5.3.99.3 | 0.0003 | - |
- |
Homo sapiens | eicosapentaenoic acid | |
| 5.3.99.3 | 0.0003 | - |
- |
Homo sapiens | 15-deoxy-DELTA12,14-prostaglandin J2 | |
| 5.3.99.3 | 0.00039 | - |
- |
Homo sapiens | 4-(4-chlorobenzyl)-2,6-bis[4-(trifluoromethoxy)phenyl]-4H-thieno[3,2-b]pyrrole | |
| 5.3.99.3 | 0.0011 | - |
- |
Homo sapiens | 7-hydroxy-N,N'-bis(2,4,6-trimethylphenyl)naphthalene-1,3-disulfonamide | |
| 5.3.99.3 | 0.0012 | - |
- |
Homo sapiens | cysteinyl leukotriene LTC4 | |
| 5.3.99.3 | 0.0013 | - |
- |
Homo sapiens | N-[4-chloro-3-(5-methyl-1,3-benzoxazol-2-yl)phenyl]-2-(trifluoromethyl)benzamide | |
| 5.3.99.3 | 0.0018 | - |
- |
Homo sapiens | 3-(1-benzothiophen-2-yl)-2-bromo-5-hydroxycyclopent-2-en-1-one | |
| 5.3.99.3 | 0.002 | - |
- |
Homo sapiens | 3-benzamidocarbazole | |
| 5.3.99.3 | 0.0032 | - |
- |
Homo sapiens | MK-886 | |
| 5.3.99.3 | 0.02 | - |
- |
Homo sapiens | NS-398 | |
| 5.3.99.3 | 0.044 | - |
- |
Homo sapiens | acetaminophen | |
| 5.3.99.3 | 0.08 | - |
- |
Homo sapiens | sulindac sulfide | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
