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Literature summary extracted from

  • Norman, J.P.; Perry, S.W.; Kasischke, K.A.; Volsky, D.J.; Gelbard, H.A.
    HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons (2007), J. Immunol., 178, 869-876.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.9 medicine in HIV-associated dementia, cortical neurons demonstrate decreased respiration upon HIV-1 neurotoxin trans activator of transcription proteint treatment, consistent with inhibition of the enzyme Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 HIV-1 neurotoxin trans activator of transcription protein inhibits the electron transport chain in a concentration-dependent manner. A concentration of 5 ng/ml, 50 ng/ml, and 10 microg/ml inhibit activity to 84, 47, and 35% of control, respectively Rattus norvegicus
7.1.1.9 potassium cyanide
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Rattus norvegicus
-
 Sprague-Dawley rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 embryo
-
 Rattus norvegicus
-
7.1.1.9 neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?