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Literature summary extracted from

  • Kim, S.J.; Zhang, Z.; Sarkar, C.; Tsai, P.C.; Lee, Y.C.; Dye, L.; Mukherjee, A.B.
    Palmitoyl protein thioesterase-1 deficiency impairs synaptic vesicle recycling at nerve terminals, contributing to neuropathology in humans and mice (2008), J. Clin. Invest., 118, 3075-3086.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.1.2.22 PPT1-KO mice are generated by gene targeting in ES cells Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.2.22 synaptic vesicle
-
 Mus musculus 8021
-
3.1.2.22 synaptic vesicle
-
 Homo sapiens 8021
-
3.1.2.22 synaptosome
-
 Mus musculus
-
-
3.1.2.22 synaptosome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.1.2.2 additional information Mus musculus PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis ?
-
 ?
3.1.2.22 additional information Mus musculus PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles ?
-
 ?
3.1.2.22 additional information Homo sapiens PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O Mus musculus palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture palmitate + protein
-
 r
3.1.2.22 palmitoyl-[protein] + H2O Homo sapiens palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture palmitate + protein
-
 r

Organism

EC Number Organism UniProt Comment Textmining
3.1.2.2 Homo sapiens P50897
-
-
3.1.2.2 Mus musculus
-
-
-
3.1.2.22 Homo sapiens
-
-
-
3.1.2.22 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.2.2 brain PPT1 is localized in the presynaptic compartment Mus musculus
-
3.1.2.2 brain PPT1 is localized in the presynaptic compartment and is most likely associated with the synaptosomes and synaptic vesicles. PPT1 deficiency causes an abnormally low level of synaptic vesicle proteins in the soluble fractions of the postmortem brain tissues from an infantile neuronal ceroid lipofuscinosis patient Homo sapiens
-
3.1.2.22 brain postmortem from patient with infantile neuronal ceroid lipofuscinosis (INCL) caused by PPT1 deficiency Homo sapiens
-
3.1.2.22 neuronal cell line primary cortical neuron culture from tissue of PPT1 knockout mice that mimic infantile neuronal ceroid lipofuscinosis Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.2.2 additional information PPT1-knockout mice, PPT1 deficiency causes persistent membrane anchorage of the palmitoylated synaptic vesicle proteins, which hinder the recycling of the vesicle components that normally fuse with the presynaptic plasma membrane during synaptic vesicle exocytosis Mus musculus ?
-
 ?
3.1.2.22 additional information PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles Mus musculus ?
-
 ?
3.1.2.22 additional information PPT1 deficiency leads to abnormally low levels of soluble synaptic vesicle proteins like synaptobrevin 2 and SNAP25, that are known to undergo palmitoylation and are critical for fusion, exocytosis, recycling, and regeneration of fresh synaptic vesicles Homo sapiens ?
-
 ?
3.1.2.22 palmitoyl-[protein] + H2O palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture Mus musculus palmitate + protein
-
 r
3.1.2.22 palmitoyl-[protein] + H2O palmitoylation plays critical roles in diverse biological functions, including membrane anchorage, vesicular transport, signal transduction and the maintenance of cellular architecture Homo sapiens palmitate + protein
-
 r

Synonyms

EC Number Synonyms Comment Organism
3.1.2.2 palmitoyl protein thioesterase-1
-
 Mus musculus
3.1.2.2 palmitoyl protein thioesterase-1
-
 Homo sapiens
3.1.2.2 PPT1
-
 Mus musculus
3.1.2.2 PPT1
-
 Homo sapiens
3.1.2.22 palmitoyl protein thioesterase-1
-
 Mus musculus
3.1.2.22 palmitoyl protein thioesterase-1
-
 Homo sapiens
3.1.2.22 PPT1
-
 Mus musculus
3.1.2.22 PPT1
-
 Homo sapiens