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Literature summary extracted from

  • Roy, B.; Halvey, E.J.; Garthwaite, J.
    An enzyme-linked receptor mechanism for nitric oxide-activated guanylyl cyclase (2008), J. Biol. Chem., 283, 18841-18851.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 BAY 41-2272 allosteric activator Bos taurus
4.6.1.2 CO
-
 Bos taurus
4.6.1.2 NO about 5000fold activation over basal level, mechanism for NO receptor activation and its modulation by GTP, ATP, and allosteric agents, model formation comprising a module in which NO, the nucleotides, and allosteric agents bind and the protein undergoes a conformational change, dovetailing with a catalytic module where GTP is converted to cGMP and diphosphate, enzyme-linked receptor mechanism, overview Bos taurus
4.6.1.2 YC-1 allosteric activator Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 ATP inhibition by ATP of GC activity stimulated by NO Bos taurus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.6.1.2 additional information
-
 additional information activation kinetics and thermodynamics, binding of GTP and NO, overview Bos taurus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Bos taurus
-
 3',5'-cyclic GMP + diphosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
4.6.1.2 from lung Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 lung
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Bos taurus 3',5'-cyclic GMP + diphosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 soluble guanylyl cyclase
-
 Bos taurus