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Literature summary extracted from

  • Li, Y.; DAurelio, M.; Deng, J.H.; Park, J.S.; Manfredi, G.; Hu, P.; Lu, J.; Bai, Y.
    An assembled complex IV maintains the stability and activity of complex I in mammalian mitochondria (2007), J. Biol. Chem., 282, 17557-17562.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.2 additional information an assembled complex IV helps to maintain complex I in mammalian cells Mus musculus
7.1.1.2 additional information an assembled complex IV helps to maintain complex I in mammalian cells Homo sapiens
7.1.1.9 additional information an assembled complex IV helps to maintain complex I (NADH-ubiquinone oxidoreductase) in mammalian cells Mus musculus
7.1.1.9 additional information an assembled complex IV helps to maintain complex I (NADH-ubiquinone oxidoreductase) in mammalian cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
7.1.1.9 G6930A nonsense mutation in the mitochondrially encoded complex IV subunit 1 gene, which causes a disruption in the assembly and defective activity of complex VI Homo sapiens
7.1.1.9 additional information an assembled complex IV is required to maintain the stability of complex I in a mouse cell line with suppressed expression of subunit 4 of complex IV Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 additional information COX I mutant cybrids show a 80% reduction in complex I enzymatic activity in isolated mitochondria as compared with control cybrids Homo sapiens
7.1.1.2 additional information mouse cell lines with suppressed expression of the nuclearly encoded subunit 4 of complex IV associated with a loss of assembly of complex IV show significantly reduced level of assembled complex I and activity, whereas levels and activity of complex III are normal or up-regulated Mus musculus
7.1.1.2 rotenone completely obstructs electron transfer through complex I Mus musculus
7.1.1.9 potassium cyanide 2 mM inhibits electron flow from complex IV to oxygen Mus musculus
7.1.1.9 Sodium azide 5 mM inhibits electron flow from complex IV to oxygen Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Mus musculus 5739
-
7.1.1.2 mitochondrion
-
 Homo sapiens 5739
-
7.1.1.9 mitochondrion
-
 Mus musculus 5739
-
7.1.1.9 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Homo sapiens
-
-
-
7.1.1.2 Mus musculus
-
-
-
7.1.1.9 Homo sapiens
-
-
-
7.1.1.9 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 A-9 cell
-
 Mus musculus
-
7.1.1.2 additional information transmitochondrial cell line, cybrids from a patient with a multisystem mitochondrial disorder with a G6930A nonsense mutation in the COX I gene. G6930A mutation causes a disruption in the assembly and defective activity of complex VI Homo sapiens
-
7.1.1.9 143B cell
-
 Homo sapiens
-
7.1.1.9 A-9 cell
-
 Mus musculus
-
7.1.1.9 additional information in C1 cells, C2 cells and C3 cells steady state level of complex I is significantly reduced due to a defective assembly of complex IV. Also present in 4A cells Mus musculus
-
7.1.1.9 osteosarcoma cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 ubiquinone + NADH + H+
-
 Mus musculus ubiquinol + NAD+
-
 ?
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Mus musculus oxidized cytochrome c + H2O
-
 ?
7.1.1.9 reduced cytochrome c + O2 + H+
-
 Homo sapiens oxidized cytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Mus musculus
7.1.1.2 complex I
-
 Homo sapiens
7.1.1.2 NADH-ubiquinone oxidoreductase
-
 Mus musculus
7.1.1.2 NADH-ubiquinone oxidoreductase
-
 Homo sapiens
7.1.1.9 COX I
-
 Mus musculus
7.1.1.9 COX IV
-
 Mus musculus
7.1.1.9 COX IV
-
 Homo sapiens
7.1.1.9 cytochrome c oxidase
-
 Mus musculus
7.1.1.9 cytochrome c oxidase
-
 Homo sapiens