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Literature summary extracted from

  • Baxter, N.J.; Blackburn, G.M.; Marston, J.P.; Hounslow, A.M.; Cliff, M.J.; Bermel, W.; Williams, N.H.; Hollfelder, F.; Wemmer, D.E.; Waltho, J.P.
    Anionic charge is prioritized over geometry in aluminum and magnesium fluoride transition state analogs of phosphoryl transfer enzymes (2008), J. Am. Chem. Soc., 130, 3952-3958.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
5.4.2.6 fluoride
-
 Lactococcus lactis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.3.3 Al3+ at near-physiological ratios of aluminum to magnesium, aluminum can dominate over magnesium in the enzyme-metal fluoride inhibitory TSA complexes, aluminium is the more likely origin of some of the physiological effects of fluoride Methanocaldococcus jannaschii
3.1.3.3 Mg2+ at near-physiological ratios of aluminum to magnesium, aluminum can dominate over magnesium in the enzyme-metal fluoride inhibitory TSA complexes Methanocaldococcus jannaschii
5.4.2.6 Mg2+ required for activity Lactococcus lactis

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.3 Methanocaldococcus jannaschii Q58989
-
-
5.4.2.6 Lactococcus lactis
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
3.1.3.3 additional information
-
 aluminum fluoride transition state analogs (TSA) complexes analyzed, NMR spectra indicated, pH titration, chemical shifts of the 19F NMR resonances not markedly affected by pH Methanocaldococcus jannaschii

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.4.2.6 beta-D-Glucose 1-phosphate
-
 Lactococcus lactis beta-D-Glucose 6-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.3 PSP
-
 Methanocaldococcus jannaschii
5.4.2.6 beta-PGM
-
 Lactococcus lactis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
3.1.3.3 6.4 9.2 fluoride chemical shifts constant throughout the pH range examined Methanocaldococcus jannaschii