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Literature summary extracted from

  • Ellis, D.Z.; Dismuke, W.M.; Chokshi, B.M.
    Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork (2008), Invest. Ophthalmol. Vis. Sci., 50, 1808-1813.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
4.6.1.2 diethylenetriamine nitric oxide
-
 Sus scrofa
4.6.1.2 NO activates the soluble guanylate cyclase, the activation is abolished by 1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one Homo sapiens
4.6.1.2 NO activates the soluble guanylate cyclase, the activation is abolished by 1H-[1,2,4]oxadiazolo[4.3a]quinoxalin-1-one Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
4.6.1.2 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one complete inhibition at 0.001 mM Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
4.6.1.2 soluble
-
 Homo sapiens
-
-
4.6.1.2 soluble
-
 Sus scrofa
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.6.1.2 GTP Homo sapiens
-
 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP Sus scrofa
-
 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP Sus scrofa
-
 3',5'-cyclic-GMP + diphosphate
-
 ?
4.6.1.2 additional information Homo sapiens sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye ?
-
 ?
4.6.1.2 additional information Sus scrofa sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.6.1.2 Homo sapiens
-
-
-
4.6.1.2 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
4.6.1.2 eye
-
 Sus scrofa
-
4.6.1.2 eye anterior segment Homo sapiens
-
4.6.1.2 eye anterior segment Sus scrofa
-
4.6.1.2 reticulum trabeculare
-
 Sus scrofa
-
4.6.1.2 trabecular meshwork
-
 Homo sapiens
-
4.6.1.2 trabecular meshwork
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.6.1.2 GTP
-
 Homo sapiens 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP
-
 Sus scrofa 3',5'-cyclic GMP + diphosphate
-
 ?
4.6.1.2 GTP
-
 Sus scrofa 3',5'-cyclic-GMP + diphosphate
-
 ?
4.6.1.2 additional information sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye Homo sapiens ?
-
 ?
4.6.1.2 additional information sGC mediates the NO-induced aqueous humor secretion and increased outflow facility from the eye Sus scrofa ?
-
 ?

Subunits

EC Number Subunits Comment Organism
4.6.1.2 dimer the enzyme is active as a heterodimer of alpha and beta subunits, but probably requires additional components for activity Homo sapiens
4.6.1.2 dimer the enzyme is active as a heterodimer of alpha and beta subunits, but probably requires additional components for activity Sus scrofa

Synonyms

EC Number Synonyms Comment Organism
4.6.1.2 sGC
-
 Homo sapiens
4.6.1.2 sGC
-
 Sus scrofa
4.6.1.2 soluble guanylate cyclase
-
 Homo sapiens
4.6.1.2 soluble guanylate cyclase
-
 Sus scrofa
4.6.1.2 soluble guanylyl cyclase
-
 Sus scrofa

General Information

EC Number General Information Comment Organism
4.6.1.2 physiological function activation of sGC is involved in the nitric oxide-induced increases in outflow facility of the eye Sus scrofa