EC Number | Application | Comment | Organism |
---|---|---|---|
2.2.1.1 | medicine | is crucial for optimal brain function. Abnormal transketolase expression and/or activity are implicated in a number of diseases where thiamin availability is low, including Wernicke-Korsakoffs Syndrome and alcoholism | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.2.1.1 | additional information | activity of transketolase is significantly reduced in brains of alcoholic patients with Wernicke-Korsakoffs Syndrome. Reduced transketolase protein expression levels in autopsied prefrontal white and grey matter and cerebellar vermis samples from neurologically uncomplicated alcoholics and alcoholics with liver cirrhosis | Homo sapiens |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.2.1.1 | 70000 | - |
2 * 70000 | Escherichia coli |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.2.1.1 | Escherichia coli | - |
- |
- |
2.2.1.1 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.2.1.1 | - |
Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.2.1.1 | brain | - |
Homo sapiens | - |
2.2.1.1 | erythrocyte | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.2.1.1 | D-xylulose 5-phosphate + D-ribose 5-phosphate | - |
Homo sapiens | sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.2.1.1 | homodimer | 2 * 70000 | Escherichia coli |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
2.2.1.1 | thiamine diphosphate | - |
Homo sapiens |