BRENDA - Enzyme Database

Tryptophan metabolites as potent inhibitors of aldehyde dehydrogenase activity and potential alcoholism-aversion therapeutic agents

Badawy, A.A.; Morgan, C.J.; Int. Congr. Ser. 1304, 344-351 (2007)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.3
3-hydroxyanthranilic acid
46% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
3-hydroxykynurenine
55% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
5-hydroxytryptophan
23% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
Disulfiram
42% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
Disulfiram
72% inhibition at 0.002 mM
Saccharomyces cerevisiae
1.2.1.3
harman
18% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
indol-3-ylpyruvic acid
30% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
indol-3-ylpyruvic acid
55% inhibition at 0.002 mM
Saccharomyces cerevisiae
1.2.1.3
Kynurenic acid
40% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
kynurenine
24% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
norharman
23% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
xanthurenic acid
56% inhibition at 0.1 mM
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.2.1.3
mitochondrion
-
Rattus norvegicus
5739
-
1.2.1.3
mitochondrion
-
Saccharomyces cerevisiae
5739
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.1.3
Rattus norvegicus
-
-
-
1.2.1.3
Saccharomyces cerevisiae
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.2.1.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.3
acetaldehyde + NAD+ + H2O
-
692623
Rattus norvegicus
acetate + NADH + H+
-
-
-
?
1.2.1.3
acetaldehyde + NAD+ + H2O
-
692623
Saccharomyces cerevisiae
acetate + NADH + H+
-
-
-
?
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.3
NAD+
-
Saccharomyces cerevisiae
1.2.1.3
NAD+
-
Rattus norvegicus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.2.1.3
NAD+
-
Saccharomyces cerevisiae
1.2.1.3
NAD+
-
Rattus norvegicus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.2.1.3
3-hydroxyanthranilic acid
46% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
3-hydroxykynurenine
55% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
5-hydroxytryptophan
23% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
Disulfiram
42% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
Disulfiram
72% inhibition at 0.002 mM
Saccharomyces cerevisiae
1.2.1.3
harman
18% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
indol-3-ylpyruvic acid
30% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
indol-3-ylpyruvic acid
55% inhibition at 0.002 mM
Saccharomyces cerevisiae
1.2.1.3
Kynurenic acid
40% inhibition at 0.002 mM
Rattus norvegicus
1.2.1.3
kynurenine
24% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
norharman
23% inhibition at 0.1 mM
Saccharomyces cerevisiae
1.2.1.3
xanthurenic acid
56% inhibition at 0.1 mM
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.2.1.3
mitochondrion
-
Rattus norvegicus
5739
-
1.2.1.3
mitochondrion
-
Saccharomyces cerevisiae
5739
-
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.2.1.3
liver
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.1.3
acetaldehyde + NAD+ + H2O
-
692623
Rattus norvegicus
acetate + NADH + H+
-
-
-
?
1.2.1.3
acetaldehyde + NAD+ + H2O
-
692623
Saccharomyces cerevisiae
acetate + NADH + H+
-
-
-
?