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Literature summary extracted from

  • Tian, Q.; Zhang, Y.; Lu, Z.
    Partial 17alpha-hydroxylase/17,20-lyase deficiency-clinical report of five Chinese 46,XX cases (2008), Gynecol. Endocrinol., 24, 362-367.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.19 medicine partial 17alpha-hydroxylase/17,20-lyase deficiency is a very rare form of congenital adrenal hyperplasia Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.14.19 57000
-
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 adrenal cortex
-
 Homo sapiens
-
1.14.14.19 gonad
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxypregnenolone + A + H2O
-
 ?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 17alpha-hydroxylase/17,20-lyase
-
 Homo sapiens
1.14.14.19 CYP17
-
 Homo sapiens
1.14.14.19 cytochrome P450 17alpha-hydroxylase
-
 Homo sapiens
1.14.14.19 P45017alpha
-
 Homo sapiens