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Literature summary extracted from

  • Klegeris, A.; Li, J.; Bammler, T.K.; Jin, J.; Zhu, D.; Kashima, D.T.; Pan, S.; Hashioka, S.; Maguire, J.; McGeer, P.L.; Zhang, J.
    Prolyl endopeptidase is revealed following SILAC analysis to be a novel mediator of human microglial and THP-1 cell neurotoxicity (2008), Glia, 56, 675-685.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.26 alpha-synuclein plus interferon-gamma increases prolyl endopeptidase activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity Homo sapiens
3.4.21.26 interferon-gamma combination of lipopolysaccharide or interferon-gamma plus interferon-gamma upregulates prolyl endopeptidase enzymatic activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity Homo sapiens
3.4.21.26 lipopolysaccharide combination of lipopolysaccharide plus interferon-gamma upregulates prolyl endopeptidase enzymatic activity. Lipopolysaccharide, interferon-gamma or alpha-synuclein alone do not significantly upregulate prolyl endopeptidase enzymatic activity Homo sapiens

Application

EC Number Application Comment Organism
3.4.21.26 medicine inhibition of the enzyme may be a therapeutic approach to neurodegenerative disorders including Alzheimer and Parkinson diseases Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.21.26 Boc-Asn-Phe-Pro-aldehyde
-
 Homo sapiens
3.4.21.26 Z-Pro-Pro-aldehyde-dimethyl acetal
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.26 cytoplasm
-
 Homo sapiens 5737
-
3.4.21.26 endoplasmic reticulum
-
 Homo sapiens 5783
-
3.4.21.26 extracellular
-
 Homo sapiens
-
-
3.4.21.26 lysosome
-
 Homo sapiens 5764
-
3.4.21.26 membrane
-
 Homo sapiens 16020
-
3.4.21.26 mitochondrion
-
 Homo sapiens 5739
-

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.26 Homo sapiens P48147
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.26 THP-1 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.26 Z-Gly-L-Pro-4-nitroanilide + H2O
-
 Homo sapiens Z-Gly-L-Pro + 4-nitroaniline
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.26 prolyl endopeptidase
-
 Homo sapiens