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Literature summary extracted from

  • Magoulas, G.; Papaioannou, D.; Papadimou, E.; Drainas, D.
    Preparation of spermine conjugates with acidic retinoids with potent ribonuclease P inhibitory activity (2009), Eur. J. Med. Chem., 44, 2689-2695.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.26.5 acitretin
-
 Dictyostelium discoideum
3.1.26.5 all-trans-retinoic acid
-
 Dictyostelium discoideum
3.1.26.5 anthralin
-
 Dictyostelium discoideum
3.1.26.5 calcipotriol
-
 Dictyostelium discoideum
3.1.26.5 isotretinoin 13-cis-retinoic acid Dictyostelium discoideum
3.1.26.5 N1,N12-bis(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
3.1.26.5 N1,N12-bisacitretinylspermine
-
 Dictyostelium discoideum
3.1.26.5 N1-(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
3.1.26.5 N1-acitretinylspermine
-
 Dictyostelium discoideum
3.1.26.5 N4,N9-bis(all-trans-retinoyl)spermine
-
 Dictyostelium discoideum
3.1.26.5 retinoic acid
-
 Dictyostelium discoideum
3.1.26.5 retinol
-
 Dictyostelium discoideum
3.1.26.5 Ro 13-6298
-
 Dictyostelium discoideum
3.1.26.5 Ro 13-7410
-
 Dictyostelium discoideum
3.1.26.5 Ro 15-0778
-
 Dictyostelium discoideum
3.1.26.5 Ro 15-1570
-
 Dictyostelium discoideum

Organism

EC Number Organism UniProt Comment Textmining
3.1.26.5 Dictyostelium discoideum
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.26.5 pre-tRNA + H2O
-
 Dictyostelium discoideum tRNA + 5'-oligoribonucleotide
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.26.5 RNase P
-
 Dictyostelium discoideum

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.1.26.5 0.0005
-
 N1,N12-bis(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.00095
-
 N1,N12-bisacitretinylspermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.0011
-
 N4,N9-bis(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.0024
-
 N1-(all-trans-retinoyl)spermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.00245
-
 N1-acitretinylspermine at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.008
-
 acitretin at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.015
-
 all-trans-retinoic acid at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.02
-
 isotretinoin at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 0.045
-
 Ro 13-7410 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 1.475
-
 retinol at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 2.8
-
 Ro 15-0778 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 3.6
-
 Ro 15-1570 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum
3.1.26.5 4.35
-
 Ro 13-6298 at 37°C, in 50 mM Tris/HCl pH 7.6, 10 mM NH4Cl, 5 mM MgCl2, and 5 mM dithiothreitol Dictyostelium discoideum