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Literature summary extracted from

  • Zhang, W.; Go, M.L.
    Quinone reductase induction activity of methoxylated analogues of resveratrol (2007), Eur. J. Med. Chem., 42, 841-850.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.5.2 1,1'-(E)-ethene-1,2-diylbis(2-methoxybenzene) at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol Mus musculus
1.6.5.2 1,3-dimethoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol Mus musculus
1.6.5.2 1-methoxy-2-[(E)-2-(4-methoxyphenyl)ethenyl]benzene at 6.3 micromol is 1.8 times more effective than resveratrol as a quinone reductase inducer Mus musculus
1.6.5.2 1-methoxy-3-[(E)-2-(4-methoxyphenyl)ethenyl]benzene at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol Mus musculus
1.6.5.2 2-methoxy-5-[(E)-2-(4-methoxyphenyl)ethenyl]phenol at 12.5 micromol, induces quinone reductase to a greater extent than resveratrol Mus musculus
1.6.5.2 additional information compared to resveratrol, analogues with ortho-methoxy substituents are more potent inducers of quinone reductase and exert their activity in a qualitatively different manner Mus musculus
1.6.5.2 resveratrol at 25 micromol increases quinone reductase activity by 1.5fold. Resveratrol induces quinone reductase activity of the wild type Hepa-1c1c7 cells to the same extent as the mutant c1 cells that lack a phase I enzyme Mus musculus

Application

EC Number Application Comment Organism
1.6.5.2 drug development greater induction activities of the phase II enzyme quinone reductase associated with stilbenoids serve as a useful starting point for the design of improved chemopreventive agents Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
1.6.5.2 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.5.2 Hepa-1c1c7 cell
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
1.6.5.2 NAD(P)H:quinone reductase
-
 Mus musculus
1.6.5.2 Quinone reductase
-
 Mus musculus