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Literature summary extracted from

  • Swarbrick, M.M.; Havel, P.J.; Levin, A.A.; Bremer, A.A.; Stanhope, K.L.; Butler, M.; Booten, S.L.; Graham, J.L.; McKay, R.A.; Murray, S.F.; Watts, L.M.; Monia, B.P.; Bhanot, S.
    Inhibition of protein tyrosine phosphatase-1B (PTP-1B) with antisense oligonucleotides improves insulin sensitivity and increases adiponectin concentrations in monkeys (2009), Endocrinology, 150, 1670-1679.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
3.1.3.48 medicine PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes Macaca mulatta
3.1.3.48 medicine PTP-1B antagonizes insulin signaling and is a potential therapeutic target for insulin resistance associated with obesity and type 2 diabetes Macaca fascicularis

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.48 ISIS 113715 PTP-1B antisense oligonucleotide ISIS 113715 dose-dependently inhibits PTP-1B mRNA and protein expression, although ISIS 113715 reduces PTP-1B protein levels by greater than 90%, no effects are observed on protein levels of TC-PTPase Macaca fascicularis
3.1.3.48 ISIS 113715 PTP-1B antisense oligonucleotide ISIS 113715 administration reduces PTP-1B mRNA expression in both liver and adipose tissue by 40-50% but does not affect muscle PTP-1B expression Macaca mulatta

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.48 Macaca fascicularis
-
-
-
3.1.3.48 Macaca mulatta
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.3.48 adipose tissue
-
 Macaca mulatta
-
3.1.3.48 adipose tissue
-
 Macaca fascicularis
-
3.1.3.48 hepatocyte
-
 Macaca fascicularis
-
3.1.3.48 liver
-
 Macaca mulatta
-
3.1.3.48 liver
-
 Macaca fascicularis
-
3.1.3.48 muscle
-
 Macaca mulatta
-

Synonyms

EC Number Synonyms Comment Organism
3.1.3.48 protein tyrosine phosphatase-1B
-
 Macaca mulatta
3.1.3.48 protein tyrosine phosphatase-1B
-
 Macaca fascicularis
3.1.3.48 PTP-1B
-
 Macaca mulatta
3.1.3.48 PTP-1B
-
 Macaca fascicularis
3.1.3.48 TC-PTPase ´
-
 Macaca fascicularis

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.48 0.00001
-
 IC50 less than 0.00001 mM Macaca mulatta ISIS 113715
3.1.3.48 0.00001
-
 IC50 less than 0.00001 mM Macaca fascicularis ISIS 113715