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Literature summary extracted from

  • Sasseville, M.; Cote, N.; Gagnon, M.C.; Richard, F.J.
    Up-regulation of 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation (2008), Endocrinology, 149, 5568-5576.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.35 3-isobutyl-1-methylxanthine
-
Sus scrofa
3.1.4.35 sildenafil 0.01 mM sildenafil inhibits 84% and 68% of the activity measured in detergent-resistant membranes and detergent-soluble fractions, respectively; 0.01 mM sildenafil inhibits 84% and 68% of the activity measured in detergent-resistant membranes and detergent-soluble fractions, respectively Sus scrofa
3.1.4.35 zaprinast
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.35 membrane approximately 37% of cGMP degradation activity is localized in the detergent-resistant membrane Sus scrofa 16020
-
3.1.4.35 soluble approximately 45% of cGMP degradation activity is localized in the detergent-soluble fractions Sus scrofa
-
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.35 60000
-
PDE6C immunodetection shows two bands at about 60000 and 85000 Da, SDS-PAGE Sus scrofa
3.1.4.35 85000
-
PDE6C immunodetection shows two bands at about 60000 and 85000 Da, SDS-PAGE Sus scrofa
3.1.4.35 100000
-
about 100000 Da, PDE5A, SDS-PAGE Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.35 Sus scrofa
-
-
-
3.1.4.35 Sus scrofa Q864F1 fragment
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.35 oocyte
-
Sus scrofa
-
3.1.4.35 ovarian cumulus cell
-
Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.35 3',5'-cGMP + H2O
-
Sus scrofa 5'-GMP
-
?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.35 3',5'-cyclic guanosine monophosphate-specific phosphodiesterase
-
Sus scrofa
3.1.4.35 GMP-PDE
-
Sus scrofa
3.1.4.35 PDE5A
-
Sus scrofa
3.1.4.35 PDE6C
-
Sus scrofa