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Literature summary extracted from

  • Nishimura, M.; Koeda, A.; Shimizu, T.; Nakayama, M.; Satoh, T.; Narimatsu, S.; Naito, S.
    Comparison of inducibility of sulfotransferase and UDP-glucuronosyltransferase mRNAs by prototypical microsomal enzyme inducers in primary cultures of human and cynomolgus monkey hepatocytes (2008), Drug Metab. Pharmacokinet., 23, 45-53.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.4.1.17 additional information especially rifampicin, dexamethasone, and also omeprazole induce the expression of isozyme UGT1A1, and to a lesser extent of isozymes UGT1A6 and UGT1A9, overview Macaca fascicularis
2.4.1.17 additional information rifampicin, dexamethasone, and especially omeprazole induce the expression of isozyme UGT1A1, and to a much lesser extent of isozymes UGT1A6 and UGT1A9, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.17 DNA and amino acid sequence determination, realtime RT-PCR analysis Macaca fascicularis
2.4.1.17 realtime RT-PCR analysis Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.17 microsome
-
 Homo sapiens
-
-
2.4.1.17 microsome
-
 Macaca fascicularis
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor Homo sapiens
-
 UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor Macaca fascicularis
-
 UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.17 Homo sapiens
-
 female and male Caucasians
-
2.4.1.17 Macaca fascicularis Q9TSL7 isozyme UGT1A1; female and male cynomolgus monkeys
-
2.4.1.17 Macaca fascicularis Q9TSL9 isozyme UGT1A6; female and male cynomolgus monkeys
-
2.4.1.17 Macaca fascicularis Q9TSM0 isozyme UGT1A9; female and male cynomolgus monkeys
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.17 hepatocyte primary culture Homo sapiens
-
2.4.1.17 hepatocyte primary culture Macaca fascicularis
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
2.4.1.17 UDP-D-glucuronate + acceptor
-
 Macaca fascicularis UDP + acceptor beta-D-glucuronoside
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.17 UDP-glucuronosyltransferase
-
 Homo sapiens
2.4.1.17 UDP-glucuronosyltransferase
-
 Macaca fascicularis