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Literature summary extracted from

  • Okrasa, K.; Levy, C.; Hauer, B.; Baudendistel, N.; Leys, D.; Micklefield, J.
    Structure and mechanism of an unusual malonate decarboxylase and related racemases (2008), Chem. Eur. J., 14, 6609-6613.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.76 cloned and overexpressed in Escherichia coli Bordetella bronchiseptica

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.1.1.76 9.6
-
 Phenylmalonate
-
 Chelativorans sp. BNC1
4.1.1.76 10
-
 Phenylmalonate
-
 Bordetella bronchiseptica
4.1.1.76 10.7
-
 Phenylmalonate
-
 Bordetella bronchiseptica
4.1.1.76 22.2
-
 2-methyl-2-phenylmalonate
-
 Chelativorans sp. BNC1
4.1.1.76 26.9
-
 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica
4.1.1.76 41.7
-
 Phenylmalonate
-
 Pyrococcus horikoshii
4.1.1.76 123
-
 Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF
5.1.1.3 0.21
-
 D-glutamate
-
 Aquifex pyrophilus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
4.1.1.76 2-aryl-2-methylmalonate Chelativorans sp. BNC1
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate Bordetella bronchiseptica
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate Alkaliphilus metalliredigens QYMF
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate Pyrococcus horikoshii
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate Bordetella bronchiseptica RB50
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate Pyrococcus horikoshii OT-3
-
 2-arylpropionate + CO2
-
 ?
4.1.1.76 alpha-aryl-alpha-methylmalonate Bordetella bronchiseptica
-
 alpha-arylpropionate + CO2
-
 ?
4.1.1.76 alpha-aryl-alpha-methylmalonate Bordetella bronchiseptica KU1201
-
 alpha-arylpropionate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.76 Alkaliphilus metalliredigens QYMF
-
-
-
4.1.1.76 Bordetella bronchiseptica A0A0H3LJU9 RB50
-
4.1.1.76 Bordetella bronchiseptica Q05115 KU1201
-
4.1.1.76 Bordetella bronchiseptica KU1201 Q05115 KU1201
-
4.1.1.76 Bordetella bronchiseptica RB50 A0A0H3LJU9 RB50
-
4.1.1.76 Chelativorans sp. BNC1
-
-
-
4.1.1.76 Pyrococcus horikoshii O58713 OT3
-
4.1.1.76 Pyrococcus horikoshii OT-3 O58713 OT3
-
5.1.1.3 Aquifex pyrophilus P56868
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
5.1.1.3
-
 Aquifex pyrophilus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.76 2(thien-2-yl) malonate
-
 Bordetella bronchiseptica ? + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Chelativorans sp. BNC1 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Alkaliphilus metalliredigens QYMF 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Pyrococcus horikoshii 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica KU1201 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Bordetella bronchiseptica RB50 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-aryl-2-methylmalonate
-
 Pyrococcus horikoshii OT-3 2-arylpropionate + CO2
-
 ?
4.1.1.76 2-methyl-2-(naphthalen-2-yl)malonate
-
 Bordetella bronchiseptica 2-(naphthalen-2-yl)propionate + CO2
-
 ?
4.1.1.76 2-methyl-2-(thien-2-yl)malonate
-
 Bordetella bronchiseptica 2-(thien-2-yl)propionate + CO2
-
 ?
4.1.1.76 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica 2-phenylpropanoate + CO2
-
 ?
4.1.1.76 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica KU1201 2-phenylpropanoate + CO2
-
 ?
4.1.1.76 2-methyl-2-phenylpropionate
-
 Chelativorans sp. BNC1 ? + CO2
-
 ?
4.1.1.76 2-phenyl-2-methylmalonate
-
 Bordetella bronchiseptica (2R)-phenylpropionate + CO2
-
 ?
4.1.1.76 2-phenyl-2-methylmalonate
-
 Bordetella bronchiseptica KU1201 (2R)-phenylpropionate + CO2
-
 ?
4.1.1.76 alpha-aryl-alpha-methylmalonate
-
 Bordetella bronchiseptica alpha-arylpropionate + CO2
-
 ?
4.1.1.76 alpha-aryl-alpha-methylmalonate
-
 Bordetella bronchiseptica KU1201 alpha-arylpropionate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Bordetella bronchiseptica Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Chelativorans sp. BNC1 Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Pyrococcus horikoshii Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Bordetella bronchiseptica KU1201 Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Bordetella bronchiseptica RB50 Phenylacetate + CO2
-
 ?
4.1.1.76 Phenylmalonate
-
 Pyrococcus horikoshii OT-3 Phenylacetate + CO2
-
 ?
5.1.1.3 D-glutamate
-
 Aquifex pyrophilus L-glutamate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.76 AMDase
-
 Bordetella bronchiseptica
4.1.1.76 AMDase
-
 Chelativorans sp. BNC1
4.1.1.76 AMDase
-
 Alkaliphilus metalliredigens QYMF
4.1.1.76 AMDase
-
 Pyrococcus horikoshii
4.1.1.76 Arylmalonate decarboxylase
-
 Bordetella bronchiseptica
4.1.1.76 Arylmalonate decarboxylase
-
 Chelativorans sp. BNC1
4.1.1.76 Arylmalonate decarboxylase
-
 Alkaliphilus metalliredigens QYMF
4.1.1.76 Arylmalonate decarboxylase
-
 Pyrococcus horikoshii
5.1.1.3 glutamate racemase
-
 Aquifex pyrophilus
5.1.1.3 MurI
-
 Aquifex pyrophilus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
4.1.1.76 0.09
-
 Phenylmalonate
-
 Pyrococcus horikoshii
4.1.1.76 0.26
-
 Phenylmalonate
-
 Alkaliphilus metalliredigens QYMF
4.1.1.76 12.4
-
 Phenylmalonate
-
 Bordetella bronchiseptica
4.1.1.76 55.8
-
 2-methyl-2-phenylmalonate
-
 Chelativorans sp. BNC1
4.1.1.76 118
-
 Phenylmalonate
-
 Chelativorans sp. BNC1
4.1.1.76 279
-
 2-methyl-2-phenylmalonate
-
 Bordetella bronchiseptica
4.1.1.76 316
-
 Phenylmalonate
-
 Bordetella bronchiseptica
5.1.1.3 3.3
-
 D-glutamate
-
 Aquifex pyrophilus