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Literature summary extracted from

  • Du, J.; Liang, X.; Zeng, H.; Shu, Y.; Yao, S.; Zhu, B.; Zhuang, G.
    Effect of small interfering RNAs of cytochrome P450 17alpha-hydroxylase/17,20-lyase (CYP17) on androgen biosynthesis in theca cells (2008), Cell Biol. Int., 32, 469-472.
    View publication on PubMed

Application

EC Number Application Comment Organism
1.14.14.19 medicine the vital role of CYP17 in androgen biosynthesis makes it a potential molecular target for gene therapetutic strategy Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.19 gene CYP17, expression in HeLa cells Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
1.14.14.19 additional information downregulation of CYP17 by siRNA in HeLa cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.14.19 siRNA siRNA targeting the CYP17 gene Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxypregnenolone + A + H2O
-
?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 Homo sapiens 17,20-lyase activity 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.19 Homo sapiens
-
-
-
1.14.14.19 Homo sapiens
-
gene CYP17
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.14.14.19 HeLa cell
-
Homo sapiens
-
1.14.14.19 ovarian follicle
-
Homo sapiens
-
1.14.14.19 theca cell polycystic ovary syndrome, PCOS, theca cell Homo sapiens
-
1.14.14.19 theca cell androgen-secreting, from females with polycystic ovary syndrome undergoing hysterectomy or ovarian wedge resection Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.19 pregnenolone + AH2 + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxypregnenolone + A + H2O
-
?
1.14.14.19 progesterone + [reduced NADPH-hemoprotein reductase] + O2 17,20-lyase activity Homo sapiens 17alpha-hydroxyprogesterone + [oxidized NADPH-hemoprotein reductase] + H2O
-
?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.19 17alpha-hydroxylase/17,20-lyase
-
Homo sapiens
1.14.14.19 CYP17
-
Homo sapiens
1.14.14.19 cytochrome P450 17alpha-hydroxylase/17,20-lyase
-
Homo sapiens

Expression

EC Number Organism Comment Expression
1.14.14.19 Homo sapiens RNAi effectively reduces the expression of exogenous CYP17 in HeLa cells by up to 50%. The CYP17 mRNA and androstenedione production of theca cells are slightly, but not significantly, reduced when compared with non-specific siRNA down

General Information

EC Number General Information Comment Organism
1.14.14.19 metabolism the enzyme is important in adrogene biosynthesis Homo sapiens