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Literature summary extracted from
- Cardiovascular effects of modulators of soluble guanylyl cyclase activity (2008), Cardiovasc. Hematol. Agents Med. Chem., 6, 287-301.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Mus musculus |  |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Homo sapiens | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Rattus norvegicus | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Bos taurus | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Oryctolagus cuniculus | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Canis lupus familiaris | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site | Ovis aries | |
| 4.6.1.2 | A-350619 | a heme-dependent stimulator of sGC, structurally not related to YC-1, but synergistic to YC-1 and sodium nitroprusside for the binding site, 70fold activation as sole stimulator, 160fold in presence of YC-1 and 230fold in presence of sodium nitroprusside | Sus scrofa | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Mus musculus | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Homo sapiens | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Rattus norvegicus | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Sus scrofa | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Bos taurus | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Oryctolagus cuniculus | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Canis lupus familiaris | |
| 4.6.1.2 | A-778935 | i.e. cis-3-[2-(2,2-dimethyl-propylsulfanyl)pyridin-3-yl]-N-(3-hydroxycyclohexyl-)acrylamide, derived from the YC-1 structure, activates the enzyme is a synergistic fashion with the NO donor sodium nitroprusside | Ovis aries | |
| 4.6.1.2 | BAY 41-2272 | - |
Mus musculus | |
| 4.6.1.2 | BAY 41-2272 | - |
Homo sapiens | |
| 4.6.1.2 | BAY 41-2272 | - |
Sus scrofa | |
| 4.6.1.2 | BAY 41-2272 | - |
Bos taurus | |
| 4.6.1.2 | BAY 41-2272 | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | BAY 41-2272 | - |
Canis lupus familiaris | |
| 4.6.1.2 | BAY 41-2272 | is effective against pulmonary hypertension in a rat model | Rattus norvegicus | |
| 4.6.1.2 | BAY 41-2272 | is effective against pulmonary hypertension in an ovine model | Ovis aries | |
| 4.6.1.2 | BAY 41-8543 | - |
Mus musculus | |
| 4.6.1.2 | BAY 41-8543 | - |
Homo sapiens | |
| 4.6.1.2 | BAY 41-8543 | - |
Sus scrofa | |
| 4.6.1.2 | BAY 41-8543 | - |
Bos taurus | |
| 4.6.1.2 | BAY 41-8543 | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | BAY 41-8543 | - |
Ovis aries | |
| 4.6.1.2 | BAY 41-8543 | lowers blood pressure in normotensive dogs | Canis lupus familiaris | |
| 4.6.1.2 | BAY 41-8543 | lowers blood pressure in normotensive rats | Rattus norvegicus | |
| 4.6.1.2 | BAY 58-2667 | - |
Mus musculus | |
| 4.6.1.2 | BAY 58-2667 | - |
Bos taurus | |
| 4.6.1.2 | BAY 58-2667 | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | BAY 58-2667 | activates the heme-free sGC 200fold, the activation is increased by inhibitor 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Sus scrofa | |
| 4.6.1.2 | BAY 58-2667 | improves cardiac output accompanied with a drop in mean arterial pulmonary artery, right atrial, and pulmonary wedge pressure | Canis lupus familiaris | |
| 4.6.1.2 | BAY 58-2667 | inhaled as microparticles, it is effective in eliciting pulmonary vasodilation in lambs | Ovis aries | |
| 4.6.1.2 | BAY 58-2667 | long term treatment causes a slight decrease in systolic blood pressure | Rattus norvegicus | |
| 4.6.1.2 | BAY 58-2667 | relaxes mesocolon specimen of type 2 diabetic patients, and induces potent arterial and venous vasodilation in patients with heart failure | Homo sapiens | |
| 4.6.1.2 | BaY 63-2521 | a heme-dependent stimulator of sGC | Homo sapiens | |
| 4.6.1.2 | G protein alpha subunit | - |
Mus musculus | |
| 4.6.1.2 | G protein alpha subunit | - |
Homo sapiens | |
| 4.6.1.2 | G protein alpha subunit | - |
Rattus norvegicus | |
| 4.6.1.2 | G protein alpha subunit | - |
Sus scrofa | |
| 4.6.1.2 | G protein alpha subunit | - |
Bos taurus | |
| 4.6.1.2 | G protein alpha subunit | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | G protein alpha subunit | - |
Canis lupus familiaris | |
| 4.6.1.2 | G protein alpha subunit | - |
Ovis aries | |
| 4.6.1.2 | HMR-1766 | causes long-lasting decrease in systolic blood pressure | Sus scrofa | |
| 4.6.1.2 | HMR-1766 | chronic treatment causes reduced ex-vivo platelet adhesion and in vivo vasodilator-stimulated phosphoprotein phosphorylation | Rattus norvegicus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Mus musculus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Homo sapiens | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Rattus norvegicus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Sus scrofa | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Bos taurus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Oryctolagus cuniculus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Canis lupus familiaris | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Ovis aries | |
| 4.6.1.2 | natriuretic peptide | - |
Mus musculus | |
| 4.6.1.2 | natriuretic peptide | - |
Homo sapiens | |
| 4.6.1.2 | natriuretic peptide | - |
Rattus norvegicus | |
| 4.6.1.2 | natriuretic peptide | - |
Sus scrofa | |
| 4.6.1.2 | natriuretic peptide | - |
Bos taurus | |
| 4.6.1.2 | natriuretic peptide | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | natriuretic peptide | - |
Canis lupus familiaris | |
| 4.6.1.2 | natriuretic peptide | - |
Ovis aries | |
| 4.6.1.2 | NO | - |
Mus musculus | |
| 4.6.1.2 | NO | - |
Homo sapiens | |
| 4.6.1.2 | NO | - |
Rattus norvegicus | |
| 4.6.1.2 | NO | - |
Sus scrofa | |
| 4.6.1.2 | NO | - |
Bos taurus | |
| 4.6.1.2 | NO | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | NO | - |
Canis lupus familiaris | |
| 4.6.1.2 | NO | - |
Ovis aries | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Mus musculus | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Homo sapiens | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Rattus norvegicus | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Bos taurus | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Oryctolagus cuniculus | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Canis lupus familiaris | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site | Ovis aries | |
| 4.6.1.2 | sodium nitroprusside | synergistic to YC-1 and A-350619 for the binding site, 230fold activation in presence of A-350619 | Sus scrofa | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Mus musculus | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Homo sapiens | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Rattus norvegicus | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Bos taurus | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Oryctolagus cuniculus | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Canis lupus familiaris | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one | Ovis aries | |
| 4.6.1.2 | YC-1 | synergistic with NO, blocked by 1H-[1,2,4]oxidazolol[4,3a]quinoxalin-1-one, from rats, synergistic to A-350619 and sodium nitroprusside for the binding site, 160fold activation in presence of A-350619 | Sus scrofa | |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.6.1.2 | additional information | construction of knockout mice | Mus musculus |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Bos taurus | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Canis lupus familiaris | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Homo sapiens | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Mus musculus | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Oryctolagus cuniculus | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Ovis aries | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Rattus norvegicus | |
| 4.6.1.2 | 4H-8-bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one | i.e. NS-2028, acts via the heme domain | Sus scrofa | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Bos taurus | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Canis lupus familiaris | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Homo sapiens | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Mus musculus | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Ovis aries | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Rattus norvegicus | |
| 4.6.1.2 | 6-anilino-5,8-quinolinedione | - |
Sus scrofa | |
| 4.6.1.2 | BaY 63-2521 | the sGC inhibitor gives apositive effect in severe pulmonary hypertention patients | Homo sapiens | |
| 4.6.1.2 | methylene blue | - |
Bos taurus | |
| 4.6.1.2 | methylene blue | - |
Canis lupus familiaris | |
| 4.6.1.2 | methylene blue | - |
Homo sapiens | |
| 4.6.1.2 | methylene blue | - |
Mus musculus | |
| 4.6.1.2 | methylene blue | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | methylene blue | - |
Ovis aries | |
| 4.6.1.2 | methylene blue | - |
Rattus norvegicus | |
| 4.6.1.2 | methylene blue | - |
Sus scrofa | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Bos taurus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Canis lupus familiaris | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Homo sapiens | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Mus musculus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Oryctolagus cuniculus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Ovis aries | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Rattus norvegicus | |
| 4.6.1.2 | additional information | effects of activators and inhibitors on enzyme regulation, overview | Sus scrofa | |
| 4.6.1.2 | superoxide | - |
Bos taurus | |
| 4.6.1.2 | superoxide | - |
Canis lupus familiaris | |
| 4.6.1.2 | superoxide | - |
Homo sapiens | |
| 4.6.1.2 | superoxide | - |
Mus musculus | |
| 4.6.1.2 | superoxide | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | superoxide | - |
Ovis aries | |
| 4.6.1.2 | superoxide | - |
Rattus norvegicus | |
| 4.6.1.2 | superoxide | - |
Sus scrofa | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Bos taurus | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Canis lupus familiaris | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Homo sapiens | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Mus musculus | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Ovis aries | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Rattus norvegicus | |
| 4.6.1.2 | [1,2,4]-oxadiazolo[4,3-a]quinoxalin-1-one | - |
Sus scrofa | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 4.6.1.2 | soluble | - |
Mus musculus | - |
- |
| 4.6.1.2 | soluble | - |
Homo sapiens | - |
- |
| 4.6.1.2 | soluble | - |
Rattus norvegicus | - |
- |
| 4.6.1.2 | soluble | - |
Sus scrofa | - |
- |
| 4.6.1.2 | soluble | - |
Bos taurus | - |
- |
| 4.6.1.2 | soluble | - |
Oryctolagus cuniculus | - |
- |
| 4.6.1.2 | soluble | - |
Canis lupus familiaris | - |
- |
| 4.6.1.2 | soluble | - |
Ovis aries | - |
- |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.2 | GTP | Mus musculus | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Homo sapiens | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Rattus norvegicus | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Sus scrofa | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Bos taurus | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Oryctolagus cuniculus | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Canis lupus familiaris | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | Ovis aries | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | additional information | Rattus norvegicus | hypertension is related to reduced cGMP levels, spontaneously hypertensive rats shows reduced sGC levels, overview, sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Mus musculus | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Homo sapiens | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Sus scrofa | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Bos taurus | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Oryctolagus cuniculus | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Canis lupus familiaris | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
| 4.6.1.2 | additional information | Ovis aries | sGC role in vascular system diseases and failures, overview | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.6.1.2 | Bos taurus | - |
- |
- |
| 4.6.1.2 | Canis lupus familiaris | - |
- |
- |
| 4.6.1.2 | Homo sapiens | - |
- |
- |
| 4.6.1.2 | Mus musculus | - |
- |
- |
| 4.6.1.2 | Oryctolagus cuniculus | - |
- |
- |
| 4.6.1.2 | Ovis aries | Q8SPV3 | fragment | - |
| 4.6.1.2 | Rattus norvegicus | - |
- |
- |
| 4.6.1.2 | Sus scrofa | - |
- |
- |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Mus musculus | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Homo sapiens | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Rattus norvegicus | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Sus scrofa | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Bos taurus | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Oryctolagus cuniculus | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Canis lupus familiaris | |
| 4.6.1.2 | GTP = 3',5'-cyclic GMP + diphosphate | reaction mechanism, structure-function relationship | Ovis aries |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 4.6.1.2 | aorta | - |
Mus musculus | - |
| 4.6.1.2 | aorta | - |
Homo sapiens | - |
| 4.6.1.2 | aorta | - |
Rattus norvegicus | - |
| 4.6.1.2 | aorta | - |
Sus scrofa | - |
| 4.6.1.2 | aorta | - |
Bos taurus | - |
| 4.6.1.2 | aorta | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | aorta | - |
Canis lupus familiaris | - |
| 4.6.1.2 | aorta | - |
Ovis aries | - |
| 4.6.1.2 | artery | - |
Mus musculus | - |
| 4.6.1.2 | artery | - |
Homo sapiens | - |
| 4.6.1.2 | artery | - |
Rattus norvegicus | - |
| 4.6.1.2 | artery | - |
Bos taurus | - |
| 4.6.1.2 | artery | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | artery | pulmonary | Sus scrofa | - |
| 4.6.1.2 | artery | pulmonary | Canis lupus familiaris | - |
| 4.6.1.2 | artery | pulmonary | Ovis aries | - |
| 4.6.1.2 | blood platelet | - |
Sus scrofa | - |
| 4.6.1.2 | corpus cavernosum | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | endothelial cell | - |
Homo sapiens | - |
| 4.6.1.2 | heart | - |
Mus musculus | - |
| 4.6.1.2 | heart | - |
Homo sapiens | - |
| 4.6.1.2 | heart | - |
Rattus norvegicus | - |
| 4.6.1.2 | heart | - |
Sus scrofa | - |
| 4.6.1.2 | heart | - |
Bos taurus | - |
| 4.6.1.2 | heart | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | heart | - |
Canis lupus familiaris | - |
| 4.6.1.2 | heart | - |
Ovis aries | - |
| 4.6.1.2 | lung | - |
Mus musculus | - |
| 4.6.1.2 | lung | - |
Homo sapiens | - |
| 4.6.1.2 | lung | - |
Rattus norvegicus | - |
| 4.6.1.2 | lung | - |
Sus scrofa | - |
| 4.6.1.2 | lung | - |
Bos taurus | - |
| 4.6.1.2 | lung | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | lung | - |
Canis lupus familiaris | - |
| 4.6.1.2 | lung | - |
Ovis aries | - |
| 4.6.1.2 | smooth muscle cell | - |
Homo sapiens | - |
| 4.6.1.2 | smooth muscle cell | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | tail | - |
Rattus norvegicus | - |
| 4.6.1.2 | vascular system | - |
Mus musculus | - |
| 4.6.1.2 | vascular system | - |
Homo sapiens | - |
| 4.6.1.2 | vascular system | - |
Rattus norvegicus | - |
| 4.6.1.2 | vascular system | - |
Sus scrofa | - |
| 4.6.1.2 | vascular system | - |
Bos taurus | - |
| 4.6.1.2 | vascular system | - |
Oryctolagus cuniculus | - |
| 4.6.1.2 | vascular system | - |
Canis lupus familiaris | - |
| 4.6.1.2 | vascular system | - |
Ovis aries | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.6.1.2 | GTP | - |
Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Sus scrofa | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Oryctolagus cuniculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Canis lupus familiaris | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | - |
Ovis aries | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Mus musculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Homo sapiens | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Rattus norvegicus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Sus scrofa | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Bos taurus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Oryctolagus cuniculus | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Canis lupus familiaris | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | GTP | sGC activity plays an important role in a variety of aspects of the cardiovascular system, regulatory mechanisms, overview. sGC has an anti-proliferative effect on smooth muscle cells | Ovis aries | 3',5'-cyclic GMP + diphosphate | - |
? | |
| 4.6.1.2 | additional information | hypertension is related to reduced cGMP levels, spontaneously hypertensive rats shows reduced sGC levels, overview, sGC role in vascular system diseases and failures, overview | Rattus norvegicus | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Mus musculus | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Homo sapiens | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Sus scrofa | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Bos taurus | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Oryctolagus cuniculus | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Canis lupus familiaris | ? | - |
? | |
| 4.6.1.2 | additional information | sGC role in vascular system diseases and failures, overview | Ovis aries | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Mus musculus |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Homo sapiens |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Rattus norvegicus |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Sus scrofa |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Bos taurus |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Oryctolagus cuniculus |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Canis lupus familiaris |
| 4.6.1.2 | GTP-pyrophosphate lyase | - |
Ovis aries |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Mus musculus |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Homo sapiens |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Rattus norvegicus |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Sus scrofa |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Bos taurus |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Oryctolagus cuniculus |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Canis lupus familiaris |
| 4.6.1.2 | More | the enzyme is a member of the family of nucleotide cyclizing enzymes | Ovis aries |
| 4.6.1.2 | sGC | - |
Mus musculus |
| 4.6.1.2 | sGC | - |
Homo sapiens |
| 4.6.1.2 | sGC | - |
Rattus norvegicus |
| 4.6.1.2 | sGC | - |
Sus scrofa |
| 4.6.1.2 | sGC | - |
Bos taurus |
| 4.6.1.2 | sGC | - |
Oryctolagus cuniculus |
| 4.6.1.2 | sGC | - |
Canis lupus familiaris |
| 4.6.1.2 | sGC | - |
Ovis aries |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Mus musculus |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Homo sapiens |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Rattus norvegicus |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Sus scrofa |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Bos taurus |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Oryctolagus cuniculus |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Canis lupus familiaris |
| 4.6.1.2 | soluble guanylyl cyclase | - |
Ovis aries |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 4.6.1.2 | heme | - |
Mus musculus | |
| 4.6.1.2 | heme | - |
Homo sapiens | |
| 4.6.1.2 | heme | - |
Rattus norvegicus | |
| 4.6.1.2 | heme | - |
Sus scrofa | |
| 4.6.1.2 | heme | - |
Bos taurus | |
| 4.6.1.2 | heme | - |
Oryctolagus cuniculus | |
| 4.6.1.2 | heme | - |
Canis lupus familiaris | |
| 4.6.1.2 | heme | - |
Ovis aries | |
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Release 2023.1 (January 2023)
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