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Literature summary extracted from

  • Geng, P.; Qiu, F.; Zhu, Y.; Bai, G.
    Four acarviosin-containing oligosaccharides identified from Streptomyces coelicoflavus ZG0656 are potent inhibitors of alpha-amylase (2008), Carbohydr. Res., 343, 882-892.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.2.1.1 acarbose pH 6.5, 37°C, mixed noncompetitive inhibition, substrate: soluble amlyose Sus scrofa
3.2.1.1 acarviostatin I03 pH 6.5, 37°C, mixed noncompetitive inhibition, substrate: soluble amlyose Sus scrofa
3.2.1.1 acarviostatin II03 pH 6.5, 37°C, mixed noncompetitive inhibition, substrate: soluble amlyose Sus scrofa
3.2.1.1 acarviostatin III03 pH 6.5, 37°C, mixed noncompetitive inhibition, substrate: soluble amlyose Sus scrofa
3.2.1.1 acarviostatin IV03 pH 6.5, 37°C, mixed noncompetitive inhibition, substrate: soluble amlyose Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
3.2.1.1 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.2.1.1 pancreas
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.2.1.1 amylose + H2O pH 6.5, 37°C, inhibition studies with acarviosin-containing oligosaccharides Sus scrofa ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
3.2.1.1 37
-
 assay at Sus scrofa

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.2.1.1 6.5
-
 assay at Sus scrofa

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
3.2.1.1 0.000008
-
 acarviostatin III03 pH 6.5, 37°C, mixed noncompetitive inhibition, Ki' (dissociation constant of the enzyme-substrate-inhibitor-complex): 0.000018 mM, substrate: soluble amlyose Sus scrofa
3.2.1.1 0.000013
-
 acarviostatin II03 pH 6.5, 37°C, mixed noncompetitive inhibition, Ki' (dissociation constant of the enzyme-substrate-inhibitor-complex): 0.000018 mM, substrate: soluble amlyose Sus scrofa
3.2.1.1 0.000033
-
 acarviostatin IV03 pH 6.5, 37°C, mixed noncompetitive inhibition, Ki' (dissociation constant of the enzyme-substrate-inhibitor-complex): 0.000033 mM, substrate: soluble amlyose Sus scrofa
3.2.1.1 0.000346
-
 acarviostatin I03 pH 6.5, 37°C, mixed noncompetitive inhibition, Ki' (dissociation constant of the enzyme-substrate-inhibitor-complex): 0.008057 mM, substrate: soluble amlyose Sus scrofa
3.2.1.1 0.0021
-
 acarbose pH 6.5, 37°C, mixed noncompetitive inhibition, Ki' (dissociation constant of the enzyme-substrate-inhibitor-complex): 0.0021 mM, substrate: soluble amlyose Sus scrofa