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Literature summary extracted from

  • Spadaro, F.; Ramoni, C.; Mezzanzanica, D.; Miotti, S.; Alberti, P.; Cecchetti, S.; Iorio, E.; Dolo, V.; Canevari, S.; Podo, F.
    Phosphatidylcholine-specific phospholipase C activation in epithelial ovarian cancer cells (2008), Cancer Res., 68, 6541-6549.
    View publication on PubMed

Application

EC Number Application Comment Organism
3.1.4.3 drug development elucidation of the mechanisms responsible for aberrant phosphatidylcholine metabolism in cancer cells may allow identification of novel biomarkers of tumor progression and design of new targeted anticancer therapies Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.4.3 tricyclodecan-9-yl-potassium xanthate The recovery of both variables to their original levels in serum-restimulated (or lysophosphatidic acid-restimulated) EOC cells is strongly delayed, for at least 24 h, in the presence of the PC-PLC inhibitor tricyclodecan-9-yl-potassium xanthate (D609). The S-phase of serum-restimulated EONT cells is not sensitive to D609 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.3 cytoplasm
-
 Homo sapiens 5737
-
3.1.4.3 nucleus
-
 Homo sapiens 5634
-
3.1.4.3 plasma membrane of cancer cells Homo sapiens 5886
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.4.3 66000
-
 Western blot analysis Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.4.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.4.3 EONT cell nontumoral (normal or immortalized) counterparts (EONT) Homo sapiens
-
3.1.4.3 epithelial ovarian cancer cell different cell lines of epithelial ovarian cancer cells (EOC) compared with nontumoral (normal or immortalized) counterparts (EONT) Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.3 phosphatidylcholine + H2O
-
 Homo sapiens 1,2-diacylglycerol + phosphorylcholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.4.3 PC-PLC
-
 Homo sapiens
3.1.4.3 phosphatidylcholine-specific phospholipase C
-
 Homo sapiens
3.1.4.3 phospholipase C
-
 Homo sapiens