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Literature summary extracted from

  • McGeary, R.P.; Vella, P.; Mak, J.Y.; Guddat, L.W.; Schenk, G.
    Inhibition of purple acid phosphatase with alpha-alkoxynaphthylmethylphosphonic acids (2009), Bioorg. Med. Chem. Lett., 19, 163-166.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.3.2 (naphthalen-1-ylmethyl)phosphonic acid
-
 Phaseolus vulgaris
3.1.3.2 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid
-
 Phaseolus vulgaris
3.1.3.2 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid
-
 Sus scrofa
3.1.3.2 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid
-
 Phaseolus vulgaris
3.1.3.2 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid
-
 Sus scrofa
3.1.3.2 [hydroxy(naphthalen-1-yl)methyl]phosphonic acid
-
 Phaseolus vulgaris
3.1.3.2 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid
-
 Phaseolus vulgaris
3.1.3.2 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid
-
 Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.1.3.2 0.02
-
 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid pH 4.9 Sus scrofa
3.1.3.2 0.03
-
 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid pH 4.9 Sus scrofa
3.1.3.2 2.65
-
 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid pH 4.9 Sus scrofa
3.1.3.2 3.1
-
 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid pH 6.2 Phaseolus vulgaris
3.1.3.2 3.41
-
 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid pH 6.2 Phaseolus vulgaris
3.1.3.2 4.28
-
 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid pH 6.2 Phaseolus vulgaris
3.1.3.2 5.31
-
 [hydroxy(naphthalen-1-yl)methyl]phosphonic acid pH 6.2 Phaseolus vulgaris
3.1.3.2 5.78
-
 (naphthalen-1-ylmethyl)phosphonic acid pH 6.2 Phaseolus vulgaris

Organism

EC Number Organism UniProt Comment Textmining
3.1.3.2 Phaseolus vulgaris
-
-
-
3.1.3.2 Sus scrofa
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.3.2 (naphthalen-1-ylmethyl)phosphonic acid + H2O
-
 Phaseolus vulgaris ?
-
 ?
3.1.3.2 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid + H2O
-
 Phaseolus vulgaris ?
-
 ?
3.1.3.2 [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid + H2O
-
 Sus scrofa ?
-
 ?
3.1.3.2 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid + H2O
-
 Phaseolus vulgaris ?
-
 ?
3.1.3.2 [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid + H2O
-
 Sus scrofa ?
-
 ?
3.1.3.2 [hydroxy(naphthalen-1-yl)methyl]phosphonic acid + H2O
-
 Phaseolus vulgaris ?
-
 ?
3.1.3.2 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid + H2O
-
 Phaseolus vulgaris ?
-
 ?
3.1.3.2 [naphthalen-1-yl(octyloxy)methyl]phosphonic acid + H2O
-
 Sus scrofa ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.3.2 pPAP
-
 Sus scrofa
3.1.3.2 purple acid phosphatase
-
 Phaseolus vulgaris
3.1.3.2 purple acid phosphatase
-
 Sus scrofa
3.1.3.2 rkbPAP
-
 Phaseolus vulgaris

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
3.1.3.2 4.9
-
-
 Sus scrofa
3.1.3.2 6.2
-
-
 Phaseolus vulgaris

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.3.2 0.008
-
 pH 6.2 Phaseolus vulgaris [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid
3.1.3.2 0.02
-
 pH 4.9 Sus scrofa [(decyloxy)(naphthalen-1-yl)methyl]phosphonic acid
3.1.3.2 0.03
-
 pH 4.9 Sus scrofa [naphthalen-1-yl(octyloxy)methyl]phosphonic acid
3.1.3.2 0.1
-
 pH 6.2 Phaseolus vulgaris [naphthalen-1-yl(octyloxy)methyl]phosphonic acid
3.1.3.2 0.43
-
 pH 4.9 Sus scrofa [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid
3.1.3.2 1
-
 pH 6.2 Phaseolus vulgaris [(hexyloxy)(naphthalen-1-yl)methyl]phosphonic acid
3.1.3.2 5
-
 pH 6.2 Phaseolus vulgaris [hydroxy(naphthalen-1-yl)methyl]phosphonic acid
3.1.3.2 7
-
 value above 7 Phaseolus vulgaris (naphthalen-1-ylmethyl)phosphonic acid