EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-(3-oxomorpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-(4-hydroxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-(4-methylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-methoxy-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopiperidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(2-fluoro-4-[[5-(2-oxopyrrolidin-1-yl)-2-piperidin-1-ylbenzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-indole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(4-[[5-(1,1-dioxidoisothiazolidin-2-yl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-(4-[[5-(dimethylcarbamoyl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-[2-fluoro-4-([5-[(1-methylethyl)carbamoyl]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-[2-fluoro-4-([5-[(methoxyacetyl)(methyl)amino]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 1-cyclohexyl-2-[2-fluoro-4-[(2-morpholin-4-ylbenzyl)oxy]phenyl]-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 13-cyclohexyl-3-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-(4-[[2-(4-acetylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-(4-[[2-(4-carboxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-(4-[[2-(4-chlorophenoxy)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-(4-[[5-(acetylamino)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-[4-([5-[acetyl(1-methylethyl)amino]-2-morpholin-4-ylbenzyl]oxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-[4-([5-[acetyl(methyl)amino]-2-morpholin-4-ylbenzyl]oxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 2-[4-[(5-chloro-2-morpholin-4-ylbenzyl)oxy]-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 3-cyclohexyl-1-methyl-2-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-indole-6-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 3-[[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-yl]methoxy]-13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | 6-cyclohexyl-4-methyl-5-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid | - |
Hepacivirus C | |
2.7.7.48 | JTK-109 | potent inhibitor | Hepacivirus C |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.48 | Hepacivirus C | - |
genotype 1b | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.7.48 | nucleoside triphosphate + RNAn | - |
Hepacivirus C | diphosphate + RNAn+1 | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.48 | NS5B RNA-dependent RNA polymerase | - |
Hepacivirus C |
2.7.7.48 | RDRP | - |
Hepacivirus C |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.7.48 | 0.0000072 | - |
- |
Hepacivirus C | 13-cyclohexyl-3-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid | |
2.7.7.48 | 0.0000072 | - |
- |
Hepacivirus C | 3-cyclohexyl-1-methyl-2-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-indole-6-carboxylic acid | |
2.7.7.48 | 0.00001 | - |
- |
Hepacivirus C | 6-cyclohexyl-4-methyl-5-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-4H-thieno[3,2-b]pyrrole-2-carboxylic acid | |
2.7.7.48 | 0.000017 | - |
- |
Hepacivirus C | JTK-109 | |
2.7.7.48 | 0.000019 | - |
- |
Hepacivirus C | 3-[[4'-chloro-4-(2-oxopyrrolidin-1-yl)biphenyl-2-yl]methoxy]-13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-10-carboxylic acid | |
2.7.7.48 | 0.00003 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-indole-5-carboxylic acid | |
2.7.7.48 | 0.000042 | - |
- |
Hepacivirus C | 2-[4-([5-[acetyl(1-methylethyl)amino]-2-morpholin-4-ylbenzyl]oxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000048 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-[2-fluoro-4-([5-[(1-methylethyl)carbamoyl]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000051 | - |
- |
Hepacivirus C | 2-[4-([5-[acetyl(methyl)amino]-2-morpholin-4-ylbenzyl]oxy)-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000066 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000068 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(4-[[5-(dimethylcarbamoyl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00007 | - |
- |
Hepacivirus C | 2-(4-[[5-(acetylamino)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000071 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(4-[[5-(1,1-dioxidoisothiazolidin-2-yl)-2-morpholin-4-ylbenzyl]oxy]-2-fluorophenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00009 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-morpholin-4-yl-5-(2-oxopiperidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.000099 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-[2-fluoro-4-([5-[(methoxyacetyl)(methyl)amino]-2-morpholin-4-ylbenzyl]oxy)phenyl]-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.0001 | - |
- |
Hepacivirus C | 2-[4-[(5-chloro-2-morpholin-4-ylbenzyl)oxy]-2-fluorophenyl]-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00011 | - |
- |
Hepacivirus C | 2-(4-[[2-(4-acetylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00013 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-(4-methylpiperazin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00013 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-[2-fluoro-4-[(2-morpholin-4-ylbenzyl)oxy]phenyl]-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00015 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-(4-hydroxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00015 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[5-(2-oxopyrrolidin-1-yl)-2-piperidin-1-ylbenzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00018 | - |
- |
Hepacivirus C | 2-(4-[[2-(4-carboxypiperidin-1-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00023 | - |
- |
Hepacivirus C | 2-(4-[[2-(4-chlorophenoxy)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]-2-fluorophenyl)-1-cyclohexyl-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.00041 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-methoxy-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid | |
2.7.7.48 | 0.001 | - |
- |
Hepacivirus C | 1-cyclohexyl-2-(2-fluoro-4-[[2-(3-oxomorpholin-4-yl)-5-(2-oxopyrrolidin-1-yl)benzyl]oxy]phenyl)-1H-benzimidazole-5-carboxylic acid |