EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | (R)-2-[3-(diethoxyphosphoryl)phenylamino]-3-hydroxypropionic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | (S)-2-[3-(diethoxyphosphoryl)phenylamino]-3-hydroxypropionic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | (S)-3-hydroxy-2-(3-methylsulfanylphenylamino)propionic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | (S)-3-hydroxy-2-(3-sulfamoylphenylamino)propionic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | 3-((R)-1-carboxy-2-hydroxyethylamino)benzoic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | 3-((S)-1-carboxy-2-hydroxyethylamino)benzoic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | 3-(carboxymethylamino)benzoic acid | - |
Mycobacterium tuberculosis |
EC Number | Application | Comment | Organism |
---|---|---|---|
6.3.1.2 | drug development | the enzyme is a potential antimycobacterial drug target | Mycobacterium tuberculosis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | (2S)-2-amino-4-(methylsulfonyl)butanoic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid | docks at the amino acid binding site of the enzyme, structure, overview | Mycobacterium tuberculosis | |
6.3.1.2 | (3-methanesulfinylphenylamino)acetic acid | 30% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | (R)-3-hydroxy-2-(3-sulfamoylphenylamino)propionic acid | 33% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | (S)-3-hydroxy-2-(3-methanesulfinylphenylamino)propionic acid | 13% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | 2-amino-4-(hydroxyamino)butanoic acid | - |
Mycobacterium tuberculosis | |
6.3.1.2 | 2-oxo-2,3-dihydro-1H-benzimidazole-5-sulfonamide | 24% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | 3-[(1H-1,2,4-triazol-3-ylcarbonyl)amino]benzoic acid | 26% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | L-methionine sulfoximine | - |
Mycobacterium tuberculosis | |
6.3.1.2 | L-methionine-(S)-sulfoximine | docks at the amino acid binding site of the enzyme, structure, overview | Mycobacterium tuberculosis | |
6.3.1.2 | additional information | no inhibition by L-homoserine, (R)-3-hydroxy-2-(3-methanesulfinylphenylamino)propionic acid, (R)-3-hydroxy-2-(3-methylsulfanylphenylamino)propionic acid, (3-sulfamoylphenylamino)acetic acid, (3-methylsulfanylphenylamino)acetic acid, 2-amino-3-(2-phosphonomethylphenyl)propanoic acid, 2-amino-3-(2-aminomethylphenyl)propanoic acid, and methyl 2-amino-3-(2-phosphonomethylphenyl)propanoate, inhibitor screening and docking studies, overview | Mycobacterium tuberculosis | |
6.3.1.2 | N-(4-hydroxy-3-sulfophenyl)glycine | 48% inhibition at 1.0 mM | Mycobacterium tuberculosis | |
6.3.1.2 | Phosphinothricin | - |
Mycobacterium tuberculosis | |
6.3.1.2 | [3-(diethoxyphosphoryl)phenylamino]acetic acid | 42% inhibition at 1.0 mM | Mycobacterium tuberculosis |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | Mg2+ | - |
Mycobacterium tuberculosis |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.1.2 | ATP + L-glutamate + NH3 | Mycobacterium tuberculosis | glnA1 is essential for Mycobacterium tuberculosis virulence | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | Mycobacterium tuberculosis H37Rv | glnA1 is essential for Mycobacterium tuberculosis virulence | ADP + phosphate + L-glutamine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
6.3.1.2 | Mycobacterium tuberculosis | P9WN39 | gene glnA1 | - |
6.3.1.2 | Mycobacterium tuberculosis H37Rv | P9WN39 | gene glnA1 | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
6.3.1.2 | ATP + L-glutamate + NH3 | glnA1 is essential for Mycobacterium tuberculosis virulence | Mycobacterium tuberculosis | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | amino acid binding site and structure, overview | Mycobacterium tuberculosis | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | glnA1 is essential for Mycobacterium tuberculosis virulence | Mycobacterium tuberculosis H37Rv | ADP + phosphate + L-glutamine | - |
? | |
6.3.1.2 | ATP + L-glutamate + NH3 | amino acid binding site and structure, overview | Mycobacterium tuberculosis H37Rv | ADP + phosphate + L-glutamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
6.3.1.2 | Glutamine synthetase | - |
Mycobacterium tuberculosis |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
6.3.1.2 | 22 | - |
assay at room temperature | Mycobacterium tuberculosis |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
6.3.1.2 | 7.5 | - |
assay at | Mycobacterium tuberculosis |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
6.3.1.2 | ATP | - |
Mycobacterium tuberculosis |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
6.3.1.2 | 0.0019 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | Phosphinothricin | |
6.3.1.2 | 0.026 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | 2-amino-4-(hydroxyamino)butanoic acid | |
6.3.1.2 | 0.033 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | (2S)-2-amino-4-(methylsulfonyl)butanoic acid | |
6.3.1.2 | 0.051 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | L-methionine-(S)-sulfoximine | |
6.3.1.2 | 0.056 | 0.058 | dependent on the solvent, pH 7.5, 22°C | Mycobacterium tuberculosis | (2S,5R)-2,6-diamino-5-hydroxyhexanoic acid | |
6.3.1.2 | 0.076 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | Phosphinothricin | |
6.3.1.2 | 0.081 | - |
pH 7.5, 22°C | Mycobacterium tuberculosis | L-methionine sulfoximine |