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Literature summary extracted from

  • Furusawa, H.; Sato, Y.; Tanaka, Y.; Inai, Y.; Amano, A.; Iwama, M.; Kondo, Y.; Handa, S.; Murata, A.; Nishikimi, M.; Goto, S.; Maruyama, N.; Takahashi, R.; Ishigami, A.
    Vitamin C is not essential for carnitine biosynthesis in vivo: verification in vitamin C-depleted senescence marker protein-30/gluconolactonase knockout mice (2008), Biol. Pharm. Bull., 31, 1673-1679.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.14.11.8 L-ascorbic acid activates, but is not essentially required Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.14.11.8 additional information construction of senescence marker protein-30/gluconolactonase knockout mice, which cannot synthesize L-ascorbate in vivo, the mutant mice nevertheless produce normal levels of carnitine when fed an L-ascorbate lacking diet Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.14.11.8 mitochondrion
-
 Mus musculus 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2 Mus musculus
-
 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.11.8 Mus musculus Q91ZE0
-
-
3.1.1.17 Mus musculus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.11.8 N6,N6,N6-trimethyl-L-lysine + 2-oxoglutarate + O2
-
 Mus musculus 3-hydroxy-N6,N6,N6-trimethyl-L-lysine + succinate + CO2
-
 ?
3.1.1.17 D-glucono-1,5-lactone + H2O
-
 Mus musculus D-gluconate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.11.8 6-N-trimethyllysine dioxygenase
-
 Mus musculus
1.14.11.8 TMLD
-
 Mus musculus
3.1.1.17 senescence marker protein-30/gluconolactonase
-
 Mus musculus
3.1.1.17 SMP30/GNL
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.14.11.8 metabolism the enzyme catalyzes the first step in the biosynthesis of carnitine Mus musculus