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Literature summary extracted from

  • Thuresson, A.; Kirsebom, L.A.; Virtanen, A.
    Inhibition of poly(A) polymerase by aminoglycosides (2007), Biochimie, 89, 1221-1227.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.7.19 PAPgamma(1-683C), a C-terminally truncated version of full length human PAPgamma with the same catalytic efficiency is expressed in Escherichia coli Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.19 5-epi-sisomycin pH-dependent inhibition, non-competitive inhibitor for ATP Homo sapiens
2.7.7.19 hygromycin B pH-dependent inhibition Homo sapiens
2.7.7.19 kanamycin A pH-dependent inhibition Homo sapiens
2.7.7.19 kanamycin B pH-dependent inhibition Homo sapiens
2.7.7.19 lividomycin A pH-dependent inhibition Homo sapiens
2.7.7.19 additional information not inhibited by neamine Homo sapiens
2.7.7.19 neomycin B an increase in pH releases the neomycin B inhibitory effect on PAPgamma Homo sapiens
2.7.7.19 paromomycin pH-dependent inhibition Homo sapiens
2.7.7.19 ribostamycin pH-dependent inhibition Homo sapiens
2.7.7.19 sisomicin pH-dependent inhibition, non-competitive inhibitor for ATP Homo sapiens
2.7.7.19 tobramycin pH-dependent inhibition Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.7.19 Mg2+ Mg2+ ions can release the inhibition of PAPgamma by aminoglycosides Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.7.19 additional information Homo sapiens the enzyme is responsible for the synthesis of the poly(A) tail at the 3'-end of eukaryotic mRNA ?
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.19 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.7.19
-
Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.7.19 ATP + RNA
-
Homo sapiens diphosphate + RNA(A)n
-
?
2.7.7.19 additional information the enzyme is responsible for the synthesis of the poly(A) tail at the 3'-end of eukaryotic mRNA Homo sapiens ?
-
?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.19 PAPgamma
-
Homo sapiens
2.7.7.19 poly(A) polymerase gamma
-
Homo sapiens