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Literature summary extracted from

  • Crow, J.A.; Middleton, B.L.; Borazjani, A.; Hatfield, M.J.; Potter, P.M.; Ross, M.K.
    Inhibition of carboxylesterase 1 is associated with cholesteryl ester retention in human THP-1 monocyte/macrophages (2008), Biochim. Biophys. Acta, 1781, 643-654.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.1 benzil specific CES inhibitor Homo sapiens
3.1.1.1 chlorpyrifos
-
 Homo sapiens
3.1.1.1 methyl paraoxon
-
 Homo sapiens
3.1.1.1 paraoxon non-specific CES inhibitor, CES1 protein expression in cells is unaffected by a 24 h paraoxon treatment, suggesting that the reduced hydrolytic activity is due to covalent inhibition of CES1 by oxons and not down-regulation of expression Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
3.1.1.1 60000
-
 SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.1 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.1 macrophage
-
 Homo sapiens
-
3.1.1.1 monocyte
-
 Homo sapiens
-
3.1.1.1 THP-1 cell isozyme CES1 but not CES2 is expressed in THP-1 cells Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.1 4-methylumbelliferyl oleate + H2O
-
 Homo sapiens 4-methylumbelliferol + oleate
-
 ?
3.1.1.1 4-nitrophenyl valerate + H2O
-
 Homo sapiens 4-nitrophenol + valerate
-
 ?
3.1.1.1 cholesteryl oleate + H2O
-
 Homo sapiens cholesterol + oleate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.1 carboxylesterase 1
-
 Homo sapiens
3.1.1.1 CEH
-
 Homo sapiens
3.1.1.1 CES1 isozyme Homo sapiens
3.1.1.1 cholesteryl ester hydrolase
-
 Homo sapiens
3.1.1.1 HCE1
-
 Homo sapiens
3.1.1.1 TGH
-
 Homo sapiens
3.1.1.1 triacylglycerol hydrolase
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
3.1.1.1 0.00000021
-
-
 Homo sapiens chlorpyrifos
3.1.1.1 0.00000029
-
-
 Homo sapiens paraoxon
3.1.1.1 0.000049
-
-
 Homo sapiens methyl paraoxon
3.1.1.1 0.00016
-
-
 Homo sapiens benzil