Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Lambert, A.J.; Buckingham, J.A.; Boysen, H.M.; Brand, M.D.
    Diphenyleneiodonium acutely inhibits reactive oxygen species production by mitochondrial complex I during reverse, but not forward electron transport (2008), Biochim. Biophys. Acta, 1777, 397-403.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 diphenyleneiodonium strongly inhibits superoxide production by complex I driven by reverse electron transport from succinate. Inhibition of superoxide production is not dependent on changes in the pH gradient. The inhibitor does not react with the flavin of complex I Rattus norvegicus
7.1.1.2 Myxothiazol complex I Q-reduction site inhibitor Rattus norvegicus
7.1.1.2 piericidin complex I Q-reduction site inhibitor Rattus norvegicus
7.1.1.2 rotenone strongly inhibits superoxide production by complex I Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Rattus norvegicus
-
 female Wistar rats
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 skeletal muscle
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 malate + pyruvate + O2
-
 Rattus norvegicus ?
-
 ?
7.1.1.2 succinate + O2 + NAD+
-
 Rattus norvegicus NADH + ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.2 complex I
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 flavin
-
 Rattus norvegicus