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Literature summary extracted from

  • Iheagwara, K.N.; Thom, S.R.; Deutschman, C.S.; Levy, R.J.
    Myocardial cytochrome oxidase activity is decreased following carbon monoxide exposure (2007), Biochim. Biophys. Acta, 1772, 1112-1116.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
7.1.1.9 medicine myocardial CcOX impairment can underlie CO induced cardiac dysfunction Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.9 CO significantly decreases myocardial CcOX activity. CcOX I protein levels significantly decrease following CO exposure while enzyme turnover number and CcOX I mRNA levels remain unchanged. Decreased CcOX activity following CO inhalation is likely due to decreased heme aa3 and CcOX subunit I content Mus musculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
7.1.1.9 0.037
-
 ferrocytochrome c following sham exposure Mus musculus
7.1.1.9 0.041
-
 ferrocytochrome c following CO exposure Mus musculus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.9 mitochondrion
-
 Mus musculus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.9 Mus musculus
-
 male C57Bl6 mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.9 heart ventricle
-
 Mus musculus
-
7.1.1.9 myocardium
-
 Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.9 ferrocytochrome c + O2 + H+
-
 Mus musculus ferricytochrome c + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
7.1.1.9 CcOX
-
 Mus musculus
7.1.1.9 cytochrome oxidase
-
 Mus musculus