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Literature summary extracted from

  • Sheth, P.R.; Hays, J.L.; Elferink, L.A.; Watowich, S.J.
    Biochemical basis for the functional switch that regulates hepatocyte growth factor receptor tyrosine kinase activation (2008), Biochemistry, 47, 4028-4038.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.10.1 hepatocyte growth factor activation of c-MET occurs in response to binding the physiological ligand hepatocyte growth factor Chlorocebus aethiops
2.7.10.1 internalin B activation of c-MET occurs in response to binding the internalin B protein of Listeria monocytogenes Chlorocebus aethiops
2.7.10.1 additional information ligand-dependent nonlinear increase in the level of c-MET phosphorylation in serum-starved Vero cells. c-MET activation response is sensitive to the dimer autophosphorylation rate. Stimulated monomeric c-MET, although clearly an active kinase molecule, is incapable of existing in an activated (i.e., phosphorylated, signaling competent) state due to synergistic effects of the biochemical properties associated with the c-MET monomeric state Chlorocebus aethiops

Application

EC Number Application Comment Organism
2.7.10.1 additional information model of c-MET activation. Relative importance of the main regulatory processes that work in concert to sharply switch between an inactive and active c-MET state. Importance of dimerization mediated changes in c-MET kinetic, biochemical, and dephosphorylation properties for enabling activation specificity. Ligand-stimulated c-MET is a highly competent signaling species and its activation is sensitive to changes in its biochemical parameters Chlorocebus aethiops

Organism

EC Number Organism UniProt Comment Textmining
2.7.10.1 Chlorocebus aethiops Q2IBA6
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-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.10.1 Vero cell
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 Chlorocebus aethiops
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Synonyms

EC Number Synonyms Comment Organism
2.7.10.1 c-met
-
 Chlorocebus aethiops
2.7.10.1 hepatocyte growth factor receptor
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 Chlorocebus aethiops