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Literature summary extracted from
- Kinetics and thermodynamics of the interchange of the morpheein forms of human porphobilinogen synthase (2008), Biochemistry, 47, 3245-3257.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 4.2.1.24 | - |
Homo sapiens |
Protein Variants
| EC Number | Protein Variants | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | F12L | naturally occurring variant | Homo sapiens |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 4.2.1.24 | 0.02 | - |
5-aminolevulinic acid | wild type, pH 9, octamer | Homo sapiens |  |
| 4.2.1.24 | 0.2 | - |
5-aminolevulinic acid | wild type, pH 7, almost octamer | Homo sapiens | |
| 4.2.1.24 | 4.5 | - |
5-aminolevulinic acid | wild type, pH 9, predominantly hexamer and/or dimer | Homo sapiens | |
| 4.2.1.24 | 4.6 | - |
5-aminolevulinic acid | F12L, pH 9 | Homo sapiens | |
| 4.2.1.24 | 18 | - |
5-aminolevulinic acid | F12L, pH 7 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 4.2.1.24 | Homo sapiens | P13716 | - |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 4.2.1.24 | - |
Homo sapiens |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 4.2.1.24 | 0.67 | - |
wild-type octamer | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 4.2.1.24 | 5-aminolevulinic acid + 5-aminolevulinic acid | - |
Homo sapiens | porphobilinogen + 2 H2O | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | dimer | pro-hexamer dimer and pro-octamer dimer, analyzed by gel filtration | Homo sapiens |
| 4.2.1.24 | hexamer | wild type, pH 8.8, catalytic turnover favors octamer, analyzed by gel filtration and anion exchange chromatography | Homo sapiens |
| 4.2.1.24 | octamer | wild type, pH 6.9 and pH 8.8, analyzed by gel filtration and anion exchange chromatography | Homo sapiens |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 4.2.1.24 | Porphobilinogen synthase | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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