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Literature summary extracted from

  • Maiti, S.; Zhang, J.; Chen, G.
    Redox regulation of human estrogen sulfotransferase (hSULT1E1) (2007), Biochem. Pharmacol., 73, 1474-1481.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.8.2.4 N-acetylcysteine a GSH inducer, increases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.8.2.4 buthionine sulfoxamine a GSH depletor, decreases SULT1E1 activity, but fails to affect the enzyme amount in Hep-G2 cells Homo sapiens
2.8.2.4 GSSG oxidized glutathione, inactivation and kinetics, adenosine 3'-phosphate 5'-phosphosulfate protects Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.8.2.4 cytosol
-
 Homo sapiens 5829
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.8.2.4 3'-phosphoadenylyl sulfate + 17beta-estradiol Homo sapiens hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estrone Homo sapiens hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
2.8.2.4 additional information Homo sapiens the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.8.2.4 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.8.2.4 Hep-G2 cell
-
 Homo sapiens
-
2.8.2.4 hepatocyte
-
 Homo sapiens
-
2.8.2.4 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.8.2.4 3'-phosphoadenylyl sulfate + 17beta-estradiol hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + 17beta-estradiol the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + 17beta-estradiol 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estrone hSULT1E1 catalyzes the sulfation of estrogens and regulates estrogen bioactivities Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
2.8.2.4 3'-phosphoadenylyl sulfate + estrone the active site of hSULT1E1 contains Cys residues. Cys83 is critical for the redox regulation of hSULT1E1 Homo sapiens adenosine 3',5'-bisphosphate + estrone 3-sulfate
-
 ?
2.8.2.4 additional information the redox regulation of hSULT1E1 may interrupt the regulation and function of estrogens under various physiological and pathological conditions Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.8.2.4 estrogen sulfotransferase
-
 Homo sapiens
2.8.2.4 SULT1E1
-
 Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.8.2.4 37
-
 assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.8.2.4 6.2
-
 assay at Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.8.2.4 additional information
-
 additional information inactivation kinetics with oxidized glutathione Homo sapiens