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Literature summary extracted from

  • Villani, M.; Subathra, M.; Im, Y.B.; Choi, Y.; Signorelli, P.; Del Poeta, M.; Luberto, C.
    Sphingomyelin synthases regulate production of diacylglycerol at the Golgi (2008), Biochem. J., 414, 31-41.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.8.27 overexpression of FLAG-tagged SMS1 or FLAG-tagged SMS2 in HeLa cells enhances de novo synthesis of sphingomyelin. expression of SMS1 and SMS2 viaSV40-transformation of WI38 fibroblasts, subcellular localization study, overview Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.8.27 additional information downregulation of SMS1 or SMS2 by siRNA oligonucleotides targeting SMS1 or SMS2 in HeLA cells reduces de novo synthesis of sphingomyelin, overview Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.8.27 Golgi membrane
-
 Homo sapiens 139
-
2.7.8.27 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.8.27 additional information Homo sapiens sphingomyelin synthases regulate production of diacylglycerol at the Golgi apparatus. Downregulation or up-regulation of SMS1 or SMS2 reduces or enhances de novo synthesis of sphingomyelin, pathway regulation, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.8.27 Homo sapiens
-
 isozymes SMS1 and SMS2
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.8.27 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.8.27 additional information sphingomyelin synthases regulate production of diacylglycerol at the Golgi apparatus. Downregulation or up-regulation of SMS1 or SMS2 reduces or enhances de novo synthesis of sphingomyelin, pathway regulation, overview Homo sapiens ?
-
 ?
2.7.8.27 phosphatidylcholine + C6-ceramide
-
 Homo sapiens ?
-
 ?
2.7.8.27 phosphatidylcholine + C6-NBD-ceramide i.e. N-[6-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]hexanoyl]-D-erythro-sphingosine, the fluorogenic derivative of C6-ceramide Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.8.27 SMS1
-
 Homo sapiens
2.7.8.27 SMS2
-
 Homo sapiens