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Literature summary extracted from

  • Watanabe, K.; Ito, S.; Yamamoto, S.
    Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) (2008), Biochem. Biophys. Res. Commun., 367, 782-786.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
5.3.99.3 dihydrolipoic acid
-
 Bos taurus
5.3.99.3 dithiothreitol
-
 Bos taurus
5.3.99.3 glutathione
-
 Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 membrane
-
 Bos taurus 16020
-
5.3.99.3 microsome
-
 Bos taurus
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Bos taurus
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Bos taurus (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 mPGE synthase-2
-
 Bos taurus
5.3.99.3 prostaglandin E synthase-2
-
 Bos taurus

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
5.3.99.3 50
-
 PGE synthase activity is completely lost at 50°C for 5 min Bos taurus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
5.3.99.3 6.5
-
 enzyme assay Bos taurus