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Literature summary extracted from

  • Grosse, C.; Heinekamp, T.; Kniemeyer, O.; Gehrke, A.; Brakhage, A.A.
    Protein kinase A regulates growth, sporulation, and pigment formation in Aspergillus fumigatus (2008), Appl. Environ. Microbiol., 74, 4923-4933.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.11 the catalytic subunit of PKA (pkaC1) is overexpressed in Aspergillus fumigatus, strains overexpressing pkaC1 show high PKA activity, reduced growth, sporulation deficiency, and formation of a dark pigment in the mycelium Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.11 additional information Aspergillus fumigatus elevated PKA activity results in activation of stress-associated proteins and of enzymes involved in protein biosynthesis and glucose catabolism, in contrast, proteins which are involved in nucleotide and amino acid biosynthesis are downregulated ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.11 Aspergillus fumigatus
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.11 ATP + Kemptide
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 Aspergillus fumigatus ADP + Kemptide phosphate
-
 ?
2.7.11.11 additional information elevated PKA activity results in activation of stress-associated proteins and of enzymes involved in protein biosynthesis and glucose catabolism, in contrast, proteins which are involved in nucleotide and amino acid biosynthesis are downregulated Aspergillus fumigatus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.11 PKA
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 Aspergillus fumigatus
2.7.11.11 protein kinase A
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 Aspergillus fumigatus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.11 ATP
-
 Aspergillus fumigatus