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Literature summary extracted from

  • Ho, T.C.; Chen, S.L.; Yang, Y.C.; Lo, T.H.; Hsieh, J.W.; Cheng, H.C.; Tsao, Y.P.
    Cytosolic phospholipase A2-alpha is an early apoptotic activator in PEDF-induced endothelial cell apoptosis (2009), Am. J. Physiol. Cell Physiol., 296, C273-C284.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.1.1.4 additional information the MAPK-dependent enzyme is induced by pigment epithelium-derived factor and activated by phosphorylation at Ser505 Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.1.1.4 dantrolene
-
 Homo sapiens
3.1.1.4 methyl arachidonyl fluorophosphonate
-
 Homo sapiens
3.1.1.4 nifedipine
-
 Homo sapiens
3.1.1.4 SB-203580
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.1.4 cytosol cPLA2-alpha is phosphorylated and translocated to the nucleus Homo sapiens 5829
-
3.1.1.4 nucleus cPLA2-alpha is phosphorylated and translocated to the nucleus Homo sapiens 5634
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
3.1.1.4 Ca2+ dependent on Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
3.1.1.4 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
3.1.1.4 phosphoprotein cPLA2-alpha is phosphorylated at Ser505, MAPK-dependent, and translocated to the nucleus Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.1.1.4 human umbilical vein endothelial cell i.e. HUVEC Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.1.4 phosphatidylcholine + H2O
-
 Homo sapiens 1-acylglycerophosphocholine + a carboxylate
-
 ?
3.1.1.4 pigment epithelium-derived 6 + H2O i.e. PED6, a synthetic substrate Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.1.1.4 cPLA2-alpha
-
 Homo sapiens
3.1.1.4 cytosolic phospholipase A2-alpha
-
 Homo sapiens