BRENDA - Enzyme Database show

Elevated microsomal prostaglandin-E synthase-1 in Alzheimers disease

Chaudhry, U.A.; Zhuang, H.; Crain, B.J.; Dore, S.; Alzheimers Dement. (N. Y.) 4, 6-13 (2008)

Data extracted from this reference:

Application
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
mPGES-1 expression is significantly elevated in Alzheimer's disease tissue
Homo sapiens
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
membrane
-
Homo sapiens
16020
-
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Homo sapiens
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
5.3.99.3
Homo sapiens
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
astrocyte
-
Homo sapiens
-
5.3.99.3
brain
-
Homo sapiens
-
5.3.99.3
cerebellum
-
Homo sapiens
-
5.3.99.3
dentate gyrus
middle frontal gyrus tissue
Homo sapiens
-
5.3.99.3
endothelial cell
-
Homo sapiens
-
5.3.99.3
microglia
-
Homo sapiens
-
5.3.99.3
neuron
-
Homo sapiens
-
5.3.99.3
pyramidal neuron
-
Homo sapiens
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
690320
Homo sapiens
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?
Application (protein specific)
EC Number
Application
Commentary
Organism
5.3.99.3
medicine
mPGES-1 expression is significantly elevated in Alzheimer's disease tissue
Homo sapiens
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
5.3.99.3
membrane
-
Homo sapiens
16020
-
5.3.99.3
microsome
-
Homo sapiens
-
-
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
Homo sapiens
-
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
5.3.99.3
astrocyte
-
Homo sapiens
-
5.3.99.3
brain
-
Homo sapiens
-
5.3.99.3
cerebellum
-
Homo sapiens
-
5.3.99.3
dentate gyrus
middle frontal gyrus tissue
Homo sapiens
-
5.3.99.3
endothelial cell
-
Homo sapiens
-
5.3.99.3
microglia
-
Homo sapiens
-
5.3.99.3
neuron
-
Homo sapiens
-
5.3.99.3
pyramidal neuron
-
Homo sapiens
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
5.3.99.3
(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
690320
Homo sapiens
(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
-
-
?