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Literature summary extracted from

  • Chaudhry, U.A.; Zhuang, H.; Crain, B.J.; Dore, S.
    Elevated microsomal prostaglandin-E synthase-1 in Alzheimers disease (2008), Alzheimers Dement. (N. Y.), 4, 6-13.
    View publication on PubMedView publication on EuropePMC

Application

EC Number Application Comment Organism
5.3.99.3 medicine mPGES-1 expression is significantly elevated in Alzheimer's disease tissue Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
5.3.99.3 membrane
-
 Homo sapiens 16020
-
5.3.99.3 microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate Homo sapiens
-
 (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
5.3.99.3 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
5.3.99.3 astrocyte
-
 Homo sapiens
-
5.3.99.3 brain
-
 Homo sapiens
-
5.3.99.3 cerebellum
-
 Homo sapiens
-
5.3.99.3 dentate gyrus middle frontal gyrus tissue Homo sapiens
-
5.3.99.3 endothelial cell
-
 Homo sapiens
-
5.3.99.3 microglia
-
 Homo sapiens
-
5.3.99.3 neuron
-
 Homo sapiens
-
5.3.99.3 pyramidal neuron
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5.3.99.3 (5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate
-
 Homo sapiens (5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
5.3.99.3 microsomal prostaglandin-E synthase-1
-
 Homo sapiens