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Literature summary extracted from

  • Arning, J.; Dringen, R.; Schmidt, M.; Thiessen, A.; Stolte, S.; Matzke, M.; Bottin-Weber, U.; Caesar-Geertz, B.; Jastorff, B.; Ranke, J.
    Structure-activity relationships for the impact of selected isothiazol-3-one biocides on glutathione metabolism and glutathione reductase of the human liver cell line Hep G2 (2008), Toxicology, 246, 203-212.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.7 4,5-dichloro-N-octylisothiazol-3-one
-
 Homo sapiens
1.8.1.7 5-chloro-N-methylisothiazol-3-one
-
 Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.7 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.7 Hep-G2 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.7 glutathione disulfide + NADPH + H+
-
 Homo sapiens glutathione + NADP+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.1.7 glutathione reductase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.7 NADPH
-
 Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
1.8.1.7 0.009
-
 cellular glutathione reductase Homo sapiens 5-chloro-N-methylisothiazol-3-one
1.8.1.7 0.014
-
 cellular glutathione reductase Homo sapiens 4,5-dichloro-N-octylisothiazol-3-one