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Literature summary extracted from
- Further insight into the impact of sodium selenite on selenoenzymes: high-dose selenite enhances hepatic thioredoxin reductase 1 activity as a consequence of liver injury (2008), Toxicol. Lett., 176, 223-229.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | carbon tetrachloride | causes marked increases in hepatic TrxR1 activity | Mus musculus |  |
| 1.8.1.9 | Thioacetamide | causes marked increases in hepatic TrxR1 activity | Mus musculus | |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | Na2SeO3 | enhances hepatic TrxR1 activity, but only on the condition that it causes liver injury | Mus musculus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | Mus musculus | Q9JMH6 | Kunming mice | - |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.9 | liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.9 | thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.8.1.9 | thioredoxin reductase 1 | - |
Mus musculus |
| 1.8.1.9 | TrxR1 | - |
Mus musculus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.9 | NADPH | - |
Mus musculus | |
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Release 2023.1 (January 2023)
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