Literature summary extracted from

Kahles, T.; Luedike, P.; Endres, M.; Galla, H.J.; Steinmetz, H.; Busse, R.; Neumann-Haefelin, T.; Brandes, R.P.
NADPH oxidase plays a central role in blood-brain barrier damage in experimental stroke (2007), Stroke, 38, 3000-3006.

Application

EC Number	Application	Comment	Organism
1.6.3.1	medicine	in brain capillary endothelial cells, hypoxia/reoxygenation induces translocation of the NAD(P)H oxidase activator Rac-1 to the membrane. Inhibition of Rac-1 prevents the ischemia/reperfusion-induced blood-brain barrier disruption. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier	Sus scrofa
1.6.3.1	medicine	inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion. In mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated. Activation of NAD(P)H oxidase promotes cerebral reactive oxygen species formation, which then leads to Rho kinase-mediated endothelial cell contraction and disruption of the blood-brain barrier	Mus musculus

Protein Variants

EC Number	Protein Variants	Comment	Organism
1.6.3.1	additional information	in mice deficient in subunit gp91phox, middle cerebral artery occlusion-induced blood-brain barrier disruption and lesion volume in ischemia-induced animals are largely attenuated	Mus musculus

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.6.3.1	apocynin	inhibition of NAD(P)H oxidase by apocynin in ischemia-induced mice prevents blood-brain barrier damage in the ischemic hemisphere I after reperfusion	Mus musculus

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.6.3.1	Mus musculus	-	-	-
1.6.3.1	Sus scrofa	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.6.3.1	brain	-	Mus musculus	-
1.6.3.1	brain	-	Sus scrofa	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)