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Literature summary extracted from

  • Hiratsuka, T.; Furihata, K.; Ishikawa, J.; Yamashita, H.; Itoh, N.; Seto, H.; Dairi, T.
    An alternative menaquinone biosynthetic pathway operating in microorganisms (2008), Science, 321, 1670-1673.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.2.2.26
-
 Thermus thermophilus
3.2.2.26
-
 Streptomyces coelicolor

Protein Variants

EC Number Protein Variants Comment Organism
3.2.2.26 additional information strain lacking the activity accumulates futalosine. Recombinant expression does not result in an active enzyme Streptomyces coelicolor

Organism

EC Number Organism UniProt Comment Textmining
1.21.98.1 Streptomyces coelicolor Q9XAP2
-
-
1.21.98.1 Streptomyces coelicolor ATCC BAA-471 Q9XAP2
-
-
3.2.2.26 Streptomyces coelicolor Q9KXN0
-
-
3.2.2.26 Thermus thermophilus Q5SKT7
-
-
3.2.2.26 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 Q5SKT7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.98.1 dehypoxanthine futalosine + S-adenosyl-L-methionine
-
 Streptomyces coelicolor cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
-
 ?
1.21.98.1 dehypoxanthine futalosine + S-adenosyl-L-methionine
-
 Streptomyces coelicolor ATCC BAA-471 cyclic dehypoxanthine futalosine + 5'-deoxyadenosine + L-methionine
-
 ?
3.2.2.26 futalosine + H2O
-
 Thermus thermophilus dehypoxanthine futalosine + hypoxanthine
-
 ?
3.2.2.26 futalosine + H2O
-
 Streptomyces coelicolor dehypoxanthine futalosine + hypoxanthine
-
 ?
3.2.2.26 futalosine + H2O
-
 Thermus thermophilus HB8 / ATCC 27634 / DSM 579 dehypoxanthine futalosine + hypoxanthine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.21.98.1 MqnC
-
 Streptomyces coelicolor

General Information

EC Number General Information Comment Organism
1.21.98.1 physiological function a gene disruption mutant requires menaquinone for growth Streptomyces coelicolor