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Literature summary extracted from

  • Tang, D.G.; Bhatia, B.; Tang, S.; Schneider-Broussard, R.
    15-Lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size) (2007), Prostaglandins Other Lipid Mediat., 82, 135-146.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.33 additional information 15-LOX2 in NHP cells is positively regulated by Sp1, the enzyme is induced in cell senescence Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.13.11.33 15-LOX2 has at least six alternatively spliced isoforms Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.33 additional information 15-LOX2 in NHP cells is negatively regulated by Sp3 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.33 cell border
-
 Homo sapiens
-
-
1.13.11.33 cytoplasm
-
 Homo sapiens 5737
-
1.13.11.33 cytoskeleton
-
 Homo sapiens 5856
-
1.13.11.33 nucleus
-
 Homo sapiens 5634
-
1.13.11.33 plasma membrane
-
 Homo sapiens 5886
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.33 arachidonate + O2 Homo sapiens 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3, but 15-LOX2 expression in NHP cells is not directly regulated by androgen/androgen receptor, overview (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 additional information Homo sapiens 15-LOX2 is a functional tumor suppressor that regulates prostate epithelial cell differentiation, senescence, and growth size, overview ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.33 Homo sapiens O15296
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.33 epithelium
-
 Homo sapiens
-
1.13.11.33 additional information 15-LOX2 expression is decreased or lost in high-grade prostate intraepithelial neoplasia and prostate cancer PCa cells Homo sapiens
-
1.13.11.33 prostate epithelial cells, 15-LOX2 has multiple alternatively spliced isoforms and is a negative cell-cycle regulator in normal prostate epithelial cells, 15-LOX2 is positively regulated by Sp1 and negatively regulated by Sp3, overview Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.33 arachidonate + O2
-
 Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate is further metabolized to (5Z,8Z,11Z,13E)-(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoate, i.e. 15(S)-HETE ?
1.13.11.33 arachidonate + O2 15-LOX2 in NHP cells is positively regulated by Sp1 and negatively regulated by Sp3, but 15-LOX2 expression in NHP cells is not directly regulated by androgen/androgen receptor, overview Homo sapiens (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyeicosa-5,8,11,13-tetraenoate
-
 ?
1.13.11.33 additional information 15-LOX2 is a functional tumor suppressor that regulates prostate epithelial cell differentiation, senescence, and growth size, overview Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.13.11.33 15-lipoxygenase 2
-
 Homo sapiens
1.13.11.33 15-LOX2
-
 Homo sapiens