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Literature summary extracted from

  • Parsonage, D.; Karplus, P.A.; Poole, L.B.
    Substrate specificity and redox potential of AhpC, a bacterial peroxiredoxin (2008), Proc. Natl. Acad. Sci. USA, 105, 8209-8214.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.11.1.24 additional information neither tert-butyl hydroperoxide nor cumene hydroperoxide demonstrate any observable inactivation of the enzyme, even when present at concentrations as high as 60 mM Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.24 0.0014
-
 H2O2 in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 0.0045
-
 Ethyl hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 0.107
-
 cumene hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 0.238
-
 tert-butyl hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.24 Salmonella enterica subsp. enterica serovar Typhimurium P0A251
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.24 cumene hydroperoxide + reduced thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium 2-phenylpropan-2-ol + oxidized thioredoxin + H2O
-
 ?
1.11.1.24 ethyl hydroperoxide + reduced thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium ? + oxidized thioredoxin
-
 ?
1.11.1.24 H2O2 + reduced thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium H2O + oxidized thioredoxin
-
 ?
1.11.1.24 linoleic acid hydroperoxide + reduced thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium ? + oxidized thioredoxin
-
 ?
1.11.1.24 tert-butyl hydroperoxide + reduced thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium tert-butanol + oxidized thioredoxin + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.11.1.24 2-Cys Prx
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 AhpC
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 alkyl hydroperoxide reductase C component
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.11.1.24 52
-
 cumene hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 52.4
-
 H2O2 in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 52.7
-
 Ethyl hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium
1.11.1.24 54.7
-
 tert-butyl hydroperoxide in 50 mM potassium phosphate pH 7.0, at 25°C Salmonella enterica subsp. enterica serovar Typhimurium

Cofactor

EC Number Cofactor Comment Organism Structure
1.11.1.24 thioredoxin
-
 Salmonella enterica subsp. enterica serovar Typhimurium